N-(2-Hydroxypropyl)methacrylamide , >98.0%(GC) , 21442-01-3
Synonym(s):
N-(2-hydroxypropyl)methacrylamide);HPMA;N-(2-Hydroxypropyl)-2-methyl-prop-2-enamide
| Pack Size | Price | Stock | Quantity |
| 1g | RMB239.20 | In Stock |
|
| 5g | RMB719.20 | In Stock |
|
| 25g | RMB2399.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 67.92°C |
| Boiling point: | 321.2±34.0 °C(Predicted) |
| Density | 1.002 g/mL ((predicted)) |
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO |
| pka | 14.43±0.20(Predicted) |
| form | powder |
| color | White to off-white |
| InChI | 1S/C7H13NO2/c1-5(2)7(10)8-4-6(3)9/h6,9H,1,4H2,2-3H3,(H,8,10) |
| InChIKey | OKPYIWASQZGASP-UHFFFAOYSA-N |
| SMILES | CC(O)CNC(=O)C(C)=C |
Description and Uses
N-(2-hydroxypropyl)methacrylamide (HPMA) is an important hydrophilic monomer. Due to the non-toxic, non-immunogenic properties and prolonged circulation time of both its homopolymers and copolymers, it is widely employed in the preparation of PHPMA copolymers (a polymer-drug conjugate) for use in the biopharmaceutical industry. For instance, poly(HPMA-co-MA-GFLG-doxorubicin) represents the first intravenous tumour-targeting polymeric prodrug to enter clinical trials. HPMA polymers and copolymers are also employed in the fabrication of biocompatible medical materials such as hydrogels[1].
Monomers to synthesize biocompetible polymers and copolymers for drug carriers, protein conjugates and hydrogels in biomedical applications.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P302+P352-P305+P351+P338-P362+P364 |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39 |
| WGK Germany | 3 |
| HS Code | 2924297099 |
| Storage Class | 11 - Combustible Solids |
