N,N-Dimethylformamide , StandardforGC,≥99.9%(GC) , 68-12-2
Synonym(s):
DMF;DMF, N,N-Dimethylmethanamide, Formic acid dimethylamide;Formic Acid Dimethylamide, DMF;Formic Acid Dimethylamide, FM approval;N,N-Dimethylformamide
CAS NO.：68-12-2
Empirical Formula: C3H7NO
Molecular Weight: 73.09
MDL number: MFCD00003284
EINECS: 200-679-5
PRODUCT Properties
| Melting point: | -61 °C (lit.) |
| alpha | 0.94 º |
| Boiling point: | 153 °C (lit.) |
| Density | 0.944 g/mL (lit.) |
| vapor density | 2.5 (vs air) |
| vapor pressure | 2.7 mm Hg ( 20 °C) |
| refractive index | n |
| Flash point: | 136 °F |
| storage temp. | Store at +5°C to +30°C. |
| solubility | water: miscible |
| pka | -0.44±0.70(Predicted) |
| form | liquid |
| color | APHA: ≤15 |
| Appearance | colorless liquid |
| PH | 7 (200g/l, H2O, 20℃) |
| Odor | Faint, ammonia-like odor detectable at 100 ppm |
| Relative polarity | 0.386 |
| Odor Threshold | 1.8ppm |
| explosive limit | 2.2-16%(V) |
| Water Solubility | soluble |
| Thermal Conductivity | 0.184 W/(m·K) at 25 ℃ |
| λmax | λ: 270 nm Amax: 1.00 λ: 275 nm Amax: 0.30 λ: 295 nm Amax: 0.10 λ: 310 nm Amax: 0.05 λ: 340-400 nm Amax: 0.01 |
| Sensitive | Hygroscopic |
| Merck | 14,3243 |
| BRN | 605365 |
| Henry's Law Constant | 1.3×102 mol/(m3Pa) at 25℃, Burkholder et al. (2019) |
| Exposure limits | ACGIH:TLV-TWA 5 ppm (15 mg/m3) OSHA:PEL-TWA 10 ppm (30 mg/m3) NIOSH:REL-TWA 10 ppm |
| Dielectric constant | 36.710000000000001 |
| InChI | 1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3 |
| InChIKey | ZMXDDKWLCZADIW-UHFFFAOYSA-N |
| SMILES | [H]C(=O)N(C)C |
| LogP | -1.010 |
| Surface tension | 35.20mN/m at 298.15K |
| Surface tension | 37.1mN/m at 20°C |
| CAS DataBase Reference | 68-12-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Formamide, N,N-dimethyl-(68-12-2) |
| IARC | 2A (Vol. 47, 71, 115) 2018 |
| EPA Substance Registry System | N,N-Dimethylformamide (68-12-2) |
Description and Uses
Dimethylformamide is a flammable, colorlessliquid with a fishy, unpleasant, amine-like odor at relativelylow concentrations. The odor threshold is 0.47100 ppm.Molecular weight= 73.11; Specific gravity (H2O:1)= 0.95;Boiling point = 153℃; Freezing/Melting point = 261℃;Vapor pressure= 3 mmHg at 20℃; Flash point = 58℃;Autoignition temperature= 444.5℃. Explosive limits are:LEL = 2.2%; UEL= 15.2% at 100℃. Hazard Identification(based on NFPA-704 M Rating System): Health 2,Flammability 2, Reactivity 0. Soluble in water.Potential Exposure: Tumorigen,Mutagen; Reproductive Effector; Human Data; Hormone,Primary Irritant. DMFA is used as a solvent for liquids,gases, and as a gasoline additive. Dimethylformamide haspowerful solvent properties for a wide range of organiccompounds. Because of its physical properties, this chemical has been used when solvents with a slow rate of evaporation are required. It finds particular usage in themanufacture of polyacrylic fibers, butadiene, purified acetylene, pharmaceuticals, dyes, petroleum products, and otherorganic chemicals.
N,N-Dimethylformamide (DMF) is a clear liquid that has been widely used in industries as a solvent, an additive, or an intermediate because of its extensive miscibility with water and most common organic solvents. Dimethylformamide solutions are used toprocess polymer fibers, films, and surface coatings; to permit easy spinning of acrylic fibers; to produce wire enamels, and as a crystallization medium in the pharmaceutical industry.
DMF can also be used for formylation with alkyllithium or Grignard reagents. It is used as a reagent in Bouveault aldehyde synthesis and also in Vilsmeier-Haack reaction. It acts as a catalyst in the synthesis of acyl chlorides. It is used for separating and refining crude from olefin gas. DMF along with methylene chloride acts as a remover of varnish or lacquers. It is also used in the manufacture of adhesives, fibers and films.
Safety
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H331-H312-H303-H319-H360-H371-H370-H372-H341-H350-H226 |
| Precautionary statements | P501-P270-P202-P240-P260-P210-P233-P201-P243-P241-P242-P271-P264-P280-P370+P378-P337+P313-P305+P351+P338-P308+P311-P362+P364-P303+P361+P353-P304+P340+P311-P403+P233-P403+P235-P405 |
| Hazard Codes | T |
| Risk Statements | 61-20/21-36 |
| Safety Statements | 53-45 |
| RIDADR | UN 2265 |
| OEB | A |
| OEL | TWA: 10 ppm (30 mg/m3) [skin] |
| WGK Germany | 1 |
| RTECS | LQ2100000 |
| F | 3-10 |
| Autoignition Temperature | 445 °C |
| Hazard Note | Toxic |
| TSCA | TSCA listed |
| HazardClass | 3 |
| PackingGroup | III |
| HS Code | 29241990 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Eye Irrit. 2 Flam. Liq. 3 Repr. 1B |
| Hazardous Substances Data | 68-12-2(Hazardous Substances Data) |
| Toxicity | LD50 in mice, rats (ml/kg): 6.8, 7.6 orally; 6.2, 4.7 i.p. (Bartsch) |
| IDLA | 500 ppm |
| REACH Registrations | Active |
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
