Difloxacin hydrochloride , Analysis standard , 91296-86-5

Synonym(s):
6-Fluoro-1-(4-fluorophenyl)-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-quinolinecarboxylic acid hydrochloride

CAS NO.：91296-86-5

Empirical Formula: C21H20ClF2N3O3

Molecular Weight: 435.85

MDL number: MFCD03840489

EINECS: 1806241-263-5

PRODUCT Properties

• Melting point: >245°C (dec.)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: Soluble in aqueous buffer
• form: powder
• color: White to off-white
• InChI: InChI=1S/C21H19F2N3O3.ClH/c1-24-6-8-25(9-7-24)19-11-18-15(10-17(19)23)20(27)16(21(28)29)12-26(18)14-4-2-13(22)3-5-14;/h2-5,10-12H,6-9H2,1H3,(H,28,29);1H
• InChIKey: JFMGBGLSDVIOHL-UHFFFAOYSA-N
• SMILES: C12C=C(C(F)=CC=1C(C(C(=O)O)=CN2C1=CC=C(F)C=C1)=O)N1CCN(C)CC1.Cl
• CAS DataBase Reference: 91296-86-5(CAS DataBase Reference)

Description and Uses

Difloxacin is a fluoroquinolone antibiotic. It is active against isolates of anaerobic bacteria, including B. fragilis, as well as Fusobacterium and Actinomyces species with MIC values ranging from ≤0.125 to 8 μg/ml. It eliminates E. coli and B. fragilis infection in a rat intra-abdominal abscess model when administered at a dose of 40 mg/kg three times per day.

A fluoroquinolone antibacterial structurally related to norfloxacin.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• WGK Germany: 3
• RTECS: VB2008975