Dipyridamole , ≥98% , 58-32-2
Synonym(s):
NSC 515776;NSC 619103
CAS NO.：58-32-2
Empirical Formula: C24H40N8O4
Molecular Weight: 504.63
MDL number: MFCD00010555
EINECS: 200-374-7
| Pack Size | Price | Stock | Quantity |
| 1G | RMB39.20 | In Stock |
|
| 5G | RMB64.00 | In Stock |
|
| 25G | RMB200.00 | In Stock |
|
| 100g | RMB768.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 165-166 °C (lit.) |
| Boiling point: | 593.96°C (rough estimate) |
| Density | 1.2046 (rough estimate) |
| refractive index | 1.6910 (estimate) |
| storage temp. | room temp |
| solubility | DMSO: soluble |
| form | powder |
| pka | pKa 6.4 (Uncertain) |
| color | yellow |
| Water Solubility | Soluble in chloroform, methanol, dilute acids, ethanol. Slightly soluble in water. |
| Merck | 14,3346 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| InChI | InChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2 |
| InChIKey | IZEKFCXSFNUWAM-UHFFFAOYSA-N |
| SMILES | C1(N(CCO)CCO)=NC(N2CCCCC2)=C2N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=N1 |
| NIST Chemistry Reference | Pyrimidine, 2,6-bis(diethanolamino)-4,8-dipiperidino-pyrimido-(5,4-d)-(58-32-2) |
Description and Uses
Dipyridamole (58-32-2) is a phosphodiesterase inhibitor (IC50=0.37, 0.38, 0.45, 0.9 and 4.5 μM for PDE11, 6, 10, 5 and 8 respectively.1,2 Potent equilibrative nucleoside transporter 1 (ENT1) inhibitor Ki=8.2 nM vs. 144.8 nM for ENT1 and ENT2 respectively.3 Antiplatelet activity.4
Dipyridamole prevents platelets sticking to the replacement heart valve and causing a blood clot on the valve. It is used to dilate blood vessels in people with peripheral arterial disease and coronary artery disease. This compound has been shown to suppress high glucose-induced osteopontin mRNA expression and protein secretion, as well as inhibit cAMP and cGMP hydrolysis. Research indicates that Dipyridamole is a non-specific nucleoside transport inhibitor with the ability to increase the effects of adenosine in sinoatrial and atrioventricular nodes. Dipyridamole is an inhibitor of ENT1 and ENT2.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 2 |
| RTECS | KK7450000 |
| HS Code | 29335990 |
| Toxicity | LD50 in rats: 8.4 g/kg orally; 208 mg/kg i.v. (Takenaka) |
