Dexlansoprazole , ≥97% , 138530-94-6

Synonym(s):
(R)-(+)2-([3-methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole;(R)-(+)-Lansoprazole

CAS NO.：138530-94-6

Empirical Formula: C16H14F3N3O2S

Molecular Weight: 369.36

MDL number: MFCD13196699

EINECS: 1308068-626-2

PRODUCT Properties

• Melting point: 66-68C
• Boiling point: 555.8±60.0 °C(Predicted)
• Density: 1.50±0.1 g/cm3(Predicted)
• storage temp.: Sealed in dry,2-8°C
• solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• pka: 9.56±0.10(Predicted)
• form: Solid
• color: Off-White to Dark Brown
• optical activity: [α]/D +142 to +158°, c =1 in chloroform-d
• Stability: Hygroscopic
• InChI: InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)/t25-/m1/s1
• InChIKey: MJIHNNLFOKEZEW-RUZDIDTESA-N
• SMILES: C1([S@@](CC2=NC=CC(OCC(F)(F)F)=C2C)=O)NC2=CC=CC=C2N=1

Description and Uses

Lansoprazole is a proton pump inhibitor that irreversibly inactivates the H⁺/K⁺-stimulated ATPase pumps in parietal cells, inhibiting gastric acid secretion and increasing intragastric pH. It is a 1:1 racemic mixture of (R)-lansoprazole and (S)-lansoprazole, both of which are pharmacologically active. (R)-Lansoprazole is an enantiomerically pure form of lansoprazole. It can inhibit acid formation in isolated canine parietal cells with an IC₅₀ value of 59 nM and inhibit the H⁺/K⁺-ATPase with an IC₅₀ value of 4.2 μM.

Acts as a gastric proton pump inhibitor and an antiulcerative

Safety

• Symbol(GHS): GHS08,GHS07
• Signal word: Warning
• Hazard statements: H317-H373
• Precautionary statements: P260-P314-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501
• WGK Germany: WGK 3
• Storage Class: 11 - Combustible Solids