Omeprazole , 98% , 73590-58-6

Synonym(s):
5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole;Antra;Losec;Omeprazole

CAS NO.：73590-58-6

Empirical Formula: C17H19N3O3S

Molecular Weight: 345.42

MDL number: MFCD00083192

EINECS: 615-996-8

PRODUCT Properties

• Melting point: 156°C
• Boiling point: 600.0±60.0 °C(Predicted)
• Density: 1.332 g/cm3
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: H₂O: 0.5 mg/mL
• pka: pKa 4.14/8.9(H2O,t =25,I=0.025) (Uncertain)
• form: solid
• color: white
• Water Solubility: Soluble in water (0.5 mg/ml), DMSO (25 mg/ml), and ethanol (4.5 mg/ml).
• Merck: 14,6845
• BCS Class: 2
• Stability: Stable, but hygroscopic and photosensitive. Incompatible with strong oxidizing agents. Store in the dark.
• Major Application: forensics and toxicology; pharmaceutical (small molecule)
• InChI: 1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
• InChIKey: SUBDBMMJDZJVOS-UHFFFAOYSA-N
• SMILES: COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C
• CAS DataBase Reference: 73590-58-6(CAS DataBase Reference)
• EPA Substance Registry System: 1H-Benzimidazole, 6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]- (73590-58-6)

Description and Uses

Omeprazole is a potent gastric antisecretory agent with selective inhibitory effect on the H⁺,K⁺-ATPase proton pump. It is highly effective in the treatment of duodenal ulcer and Zollinger-Ellison syndrome, and is reportedly superior to ranitidine in the management of reflux esophagitis.

Omeprazole is a proton pump inhibitor used to treat diseases like gastroesophageal reflux disease (GERD), used for gastric and duodenal ulcers, reflux or erosive esophagitis, and Zollinger-Ellison syndrome. It is also effective for gastric and duodenal ulcers that are ineffective with H2 receptor antagonists. Injections of Omeprazole can also be used for: 1 gastrointestinal bleeding, such as peptic and anastomic ulcer bleeding, and the prevention of severe diseases (such as cerebral hemorrhage, severe trauma, etc.) and gastric surgery caused by upper intestinal bleeding; 2 acute gastric mucosal damage complicated by stress or nonsteroidal anti-inflammatory drugs; 3 general anesthesia, post-surgery, or coma patients, to prevent acid reflux and aspiration pneumonia; 4 Combined with amoxicillin and clarithromycin, or with metronidazole and clarithromycin, it can effectively kill Helicobacter pylori (Hp).

Safety

• Symbol(GHS): GHS02,GHS06,GHS08,GHS07
• Signal word: Danger
• Hazard statements: H303-H225-H301+H311+H331-H370-H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P405-P501a-P210-P260-P280-P301+P310-P311-P305+P351+P338-P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Hazard Codes: Xi,T,F
• Risk Statements: 36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 26-36-37/39-45-36/37-16-7
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 2
• RTECS: DD9087000
• HS Code: 29333990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral; Aquatic Chronic 2; Skin Sens. 1
• Hazardous Substances Data: 73590-58-6(Hazardous Substances Data)
• Toxicity: LD50 in mice, rats (g/kg): 0.08, >0.05 i.v.; >4, >4 orally (Ekman)
• REACH Registrations: Active