Dorzolamide HCl , ≥98% , 130693-82-2

Synonym(s):
Dorzolamide hydrochloride

CAS NO.：130693-82-2

Empirical Formula: C10H17ClN2O4S3

Molecular Weight: 360.9

MDL number: MFCD00884659

EINECS: 620-304-2

PRODUCT Properties

• Melting point: 265-2670C
• alpha: D24 -8.34° (c = 1 in methanol)
• storage temp.: Keep in dark place,Inert atmosphere,2-8°C
• solubility: Soluble in water, slightly soluble in methanol, very slightly soluble in anhydrous ethanol.
• form: Solid
• color: White to Off-White
• λmax: 254nm(CHCl3:MeOH= aq.)(lit.)
• Merck: 14,3426
• BRN: 5896026
• InChI: InChI=1/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/s3
• InChIKey: OSRUSFPMRGDLAG-PPSJVSIQNA-N
• SMILES: O=S1([C@H](C[C@@H](C2C=C(SC=21)S(=O)(=O)N)NCC)C)=O.Cl |&1:2,4,r|
• CAS DataBase Reference: 130693-82-2(CAS DataBase Reference)

Description and Uses

Dorzolamide hydrochloride was introduced in the U.S.A. as eye drops for the treatment of open-angle glaucoma and ocular hypertension. Dorzolamide is a potent carbonic anhydrase inhibitor that, on topical administration, lowers intraocular pressure (IOP). In a clinical study in patients with bilateral primary open-angle glaucoma or ocular hypertension, dorzolamide (0.7-2%) was found to significantly lower IOP throughout the day. Dorzolamide has been shown to be effective as a single therapy or in combination with β-blockers.

An inhibitor of carbonic anhydrase.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H302-H373
• Precautionary statements: P260-P264-P270-P301+P312-P314-P501
• WGK Germany: 3
• RTECS: XJ9095163
• HS Code: 2935904000