2,4-Diamino-6-hydroxypyrimidine , >98.0%(HPLC) , 56-06-4

CAS NO.：56-06-4

Empirical Formula: C4H6N4O

Molecular Weight: 126.12

MDL number: MFCD00006098

EINECS: 200-254-4

PRODUCT Properties

• Melting point: 285-286 °C (dec.) (lit.)
• Boiling point: 234.22°C (rough estimate)
• Density: 1.3659 (rough estimate)
• refractive index: 1.7990 (estimate)
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: DMSO (Slightly), Methanol (Slightly)
• pka: 10.61±0.50(Predicted)
• form: Fine Crystalline Powder
• color: White to cream
• Sensitive: Light Sensitive
• Merck: 14,2981
• BRN: 125006
• InChIKey: SWELIMKTDYHAOY-UHFFFAOYSA-N
• CAS DataBase Reference: 56-06-4(CAS DataBase Reference)
• NIST Chemistry Reference: 4(1H)-pyrimidinone, 2,6-diamino-(56-06-4)
• EPA Substance Registry System: 2,6-Diamino-4(1H)-pyrimidinone (56-06-4)

Description and Uses

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective, specific inhibitor of GTP cyclohydrolase I, the rate limiting step for de novo pterin synthesis. In HUVEC cells, the IC₅₀ for inhibition of BH₄ biosynthesis is about 0.3 mM. DAHP can be used to effectively block NO production in several cell types.

It stands at the beginning of the enzyme-catalyzed cascade that starts with this seven-carbon carbohydrate and ends with the aromatic amino acids phenylalanine, tyrosine, and tryptophan

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 22-24/25-36-26
• WGK Germany: 3
• Hazard Note: Irritant
• TSCA: Yes
• HS Code: 29335995