Drospirenone , >98.0%(HPLC) , 67392-87-4

Synonym(s):
6β,7β:15β,16β -Dimethylene-3-oxo-17α-pregn-4-ene-21,17-carbolactone;Dihydrospirorenone;Drospirenone

CAS NO.：67392-87-4

Empirical Formula: C24H30O3

Molecular Weight: 366.5

MDL number: MFCD00867350

EINECS: 266-679-2

PRODUCT Properties

• Melting point: 196-200°C
• alpha: -180 º (c=0.5, chloroform)
• Boiling point: 552.2±50.0 °C(Predicted)
• Density: 1.26±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: ≥15
• form: powder
• color: white to tan
• optical activity: [α]/D -180 to -195°, c = 1 in methanol
• InChIKey: METQSPRSQINEEU-URUUTGNFNA-N
• SMILES: C[C@]12CC[C@]3([H])[C@]4(CCC(=O)C=C4[C@@H]4C[C@@H]4[C@@]3([H])[C@]1([H])[C@@H]1C[C@@H]1[C@]12CCC(=O)O1)C |&1:1,4,6,13,15,16,18,20,22,23,r|

Description and Uses

Drospirenone is a synthetic progestogen that binds to the progesterone, mineralocorticoid, and androgen receptors with binding affinities of 20, 230, and 65% relative to R5020, aldosterone , and R1881, respectively. In vivo, drospirenone inhibits spontaneous ovulation in rats (ID₅₀s = 0.3-1.0 mg/day) when administered orally or subcutaneously. Drospirenone (0.5 mg/animal) administered six times per day maintains pregnancy in ovariectomized pregnant rats. It reduces serum testosterone (Item Nos. 15645 | ISO60154) and luteinizing hormone in cynomolgus monkeys in a dose-dependent manner. Drospirenone (10 mg/animal per day) also inhibits testosterone-induced growth of the seminal vesicles and prostate in castrated rats. Formulations containing drospirenone have been used as oral contraceptives.

anti-cancer therapeutic

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H360
• Precautionary statements: P201-P202-P280-P308+P313-P405-P501
• Hazard Codes: T
• Risk Statements: 60
• Safety Statements: 36/37
• WGK Germany: 3
• RTECS: WH1299000
• HS Code: 2937230000
• Hazardous Substances Data: 67392-87-4(Hazardous Substances Data)