5′-Deoxy-5′-(methylthio)adenosine , 95% , 2457-80-9

Synonym(s):
5ʹ-Deoxy-5ʹ-methylthioadenosine - CAS 2457-80-9 - Calbiochem;Methylthioadenosine;MTA;MTA, MeSAdo

CAS NO.：2457-80-9

Empirical Formula: C11H15N5O3S

Molecular Weight: 297.33

MDL number: MFCD00010533

PRODUCT Properties

• Melting point: 210-213 °C (dec.)
• Boiling point: 642.7±65.0 °C(Predicted)
• Density: 1.85±0.1 g/cm3(Predicted)
• storage temp.: -20°C
• solubility: DMF (Sparingly), DMSO (Slightly), Methanol (Slightly)
• pka: 13.10±0.70(Predicted)
• form: White solid
• color: White to Off-White
• biological source: synthetic (organic)
• BRN: 42420
• InChI: InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1
• InChIKey: WUUGFSXJNOTRMR-IOSLPCCCSA-N
• SMILES: S(C)C[C@H]1O[C@@H](N2C3C(=C(N=CN=3)N)N=C2)[C@H](O)[C@@H]1O

Description and Uses

5′-Deoxy-5′-(methylthio)adenosine has been used as a protein methylation inhibitor to reduce E2F transcription factor 1 (E2F1) protein abundance in hepatocellular carcinoma (HCC) cells. It has also been used to inhibit histone methylation modification and study its role in hypoxia inducible factor-1 (Hif-1) nuclear transport.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: AU7410000
• F: 10-21