Ethyl bromoacetate , 98% , 105-36-2
Synonym(s):
Bromoacetic acid ethyl ester;Ethyl bromoacetate
CAS NO.：105-36-2
Empirical Formula: C4H7BrO2
Molecular Weight: 167
MDL number: MFCD00000191
EINECS: 203-290-9
PRODUCT Properties
| Melting point: | −38 °C (−36 °F; 235 K) |
| Boiling point: | 158 °C (316 °F; 431 K) |
| Density | 1.51 g/cm3 |
| vapor density | 5.8 (vs air) |
| vapor pressure | 2.6 mm Hg ( 25 °C) |
| refractive index | 1.45 |
| Flash point: | 47 °C (117 °F; 320 K) |
| storage temp. | Store below +30°C. |
| solubility | water: insoluble |
| form | liquid |
| color | Colorless to yellow |
| Specific Gravity | 1.506 |
| Odor | Pungent odour |
| Water Solubility | Miscible with ethanol, acetone, benzene and ethyl ether. Immiscible with water. |
| BRN | 506456 |
| Henry's Law Constant | 3.7×10-1 mol/(m3Pa) at 25℃, HSDB (2015) |
| Dielectric constant | 9.75 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents, water, strong acids. |
| InChI | 1S/C4H7BrO2/c1-2-7-4(6)3-5/h2-3H2,1H3 |
| InChIKey | PQJJJMRNHATNKG-UHFFFAOYSA-N |
| SMILES | BrCC(=O)OCC |
| CAS DataBase Reference | 105-36-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetic acid, bromo-, ethyl ester(105-36-2) |
| EPA Substance Registry System | Acetic acid, 2-bromo-, ethyl ester (105-36-2) |
Description and Uses
Ethyl bromoacetate is a clear, colorless tolight-yellow liquid. Molecular weight = 167.02; Boilingpoint = 159℃. Freezing point ≤－20℃; Flashpoint = 48℃. Hazard Identification (based on NFPA-704 MRating System): Health 2, Flammability 2, Reactivity 0.Insoluble in water
Ethyl bromoacetate is widely used as an alkylating reagent involved in the Reformatsky reaction to prepare the beta-hydroxy esters by reacting with carbonyl compounds. It is also used for the syntheses of witting reagent, artificial diethylstilbestrol antigen, 3-phenyl-1-naphthol and steroidal thiazolidinone derivatives. It finds applications in the preparation of reversibly photoresponsive coumarin-stabilized polymeric nanoparticles in an aqueous medium which act as a detectable drug carrier.
Safety
| Symbol(GHS) |    GHS02,GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H300+H310+H330-H318-H226 |
| Precautionary statements | P501-P270-P262-P240-P260-P210-P233-P243-P241-P242-P271-P264-P280-P284-P370+P378-P361+P364-P303+P361+P353-P301+P310+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P403+P235-P405 |
| Hazard Codes | T+ |
| Risk Statements | 26/27/28 |
| Safety Statements | 26-45-7/9-1/2 |
| RIDADR | UN 1603 |
| WGK Germany | 1 |
| RTECS | AF6000000 |
| F | 19 |
| TSCA | TSCA listed |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29159080 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 1 Dermal Acute Tox. 2 Inhalation Acute Tox. 2 Oral Flam. Liq. 3 |
| Hazardous Substances Data | 105-36-2(Hazardous Substances Data) |
| REACH Registrations | Active |
| Limited Quantities | 100ml (liquid) or 0.5 Kg (solid) |
| Excepted Quantities | Forbidden |
