Ethionamide , 98% , 536-33-4

Synonym(s):
2-Ethyl-4-pyridinecarbothioamide;Ethionamide

CAS NO.：536-33-4

Empirical Formula: C8H10N2S

Molecular Weight: 166.24

MDL number: MFCD00057361

EINECS: 208-628-9

PRODUCT Properties

• Melting point: 164 °C
• Boiling point: 167 °C / 1mmHg
• Density: 1.1332 (rough estimate)
• refractive index: 1.5500 (estimate)
• Flash point: >110°(230°F)
• storage temp.: 2-8°C
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: pKa 4.37(H2O t=25.0 I=0.025) (Uncertain)
• color: Yellow
• Water Solubility: Soluble in DMSO. Sparingly soluble in water
• Merck: 14,3737
• BCS Class: 3/1
• InChIKey: AEOCXXJPGCBFJA-UHFFFAOYSA-N
• CAS DataBase Reference: 536-33-4(CAS DataBase Reference)
• IARC: 3 (Vol. 13, Sup 7) 1987
• NIST Chemistry Reference: Ethionamide(536-33-4)
• EPA Substance Registry System: Ethionamide (536-33-4)

Description and Uses

Ethionamide is an antimycobacterial compound that is active against M. tuberculosis (MICs = 0.3-1.25 μg/ml). It is activated via oxidation by flavin monooxygenase and inhibits the InhA enzyme involved in mycolic acid biosynthesis. Formulations containing ethionamide have been used in the second-line treatment of multi-drug resistant tuberculosis.

Antibacterial (tuberculostatic).

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H302-H361
• Precautionary statements: P280-P301+P312+P330
• Hazard Codes: Xn
• Risk Statements: 22-63
• Safety Statements: 36/37
• WGK Germany: 3
• RTECS: NS0350000
• HS Code: 29333990
• Hazardous Substances Data: 536-33-4(Hazardous Substances Data)
• Toxicity: LD50 oral in rat: 1320mg/kg