Ethyl isonipecotate , 98% , 1126-09-6

Synonym(s):
Ethyl 4-piperidinecarboxylate;Piperidin-4-carboxylic acid ethyl ester

CAS NO.：1126-09-6

Empirical Formula: C8H15NO2

Molecular Weight: 157.21

MDL number: MFCD00006003

EINECS: 214-416-7

PRODUCT Properties

• Boiling point: 204 °C(lit.)
• Density: 1.02 g/mL at 25 °C(lit.)
• vapor pressure: 39.4Pa at 25℃
• refractive index: n20/D 1.459(lit.)
• Flash point: 176 °F
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• form: Liquid
• pka: 9.83±0.10(Predicted)
• color: Clear colorless to slightly brown
• Water Solubility: miscible
• BRN: 118419
• InChI: InChI=1S/C8H15NO2/c1-2-11-8(10)7-3-5-9-6-4-7/h7,9H,2-6H2,1H3
• InChIKey: RUJPPJYDHHAEEK-UHFFFAOYSA-N
• SMILES: N1CCC(C(OCC)=O)CC1
• LogP: 1.15
• CAS DataBase Reference: 1126-09-6(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl piperidine-4-carboxylate(1126-09-6)

Description and Uses

It is used as a reactant for synthesis of SMN protein modulators, β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition, nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone. It is also involved in the reactions of RhoA inhibitors for cardiovascular disease therapy and saccharin derived Mannich bases as antimicrobials and antioxidants. It is employed as a reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H227-H315-H319-H335
• Precautionary statements: P210-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P370+P378-P403+P235-P501-P210e-P261-P280a-P305+P351+P338-P405-P501a
• Hazard Codes: C,Xi
• Risk Statements: 34-36/37/38
• Safety Statements: 23-24/25-36-26
• RIDADR: UN2735
• WGK Germany: 3
• Hazard Note: Irritant
• HS Code: 29333999