A4013812
EX 527 (Selisistat) , ≥98% , 49843-98-3
Synonym(s):
6-Chloro-2,3,4,9-tetrahydro-1H-Carbazole-1-carboxamide;6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, racemic, SIRT1 Inhibitor III, SIRT2 Inhibitor IV, SIRT3 Inhibitor I, EX-527;SIRT1 Inhibitor III
| Pack Size | Price | Stock | Quantity |
| 5MG | RMB295.20 | In Stock |
|
| 10MG | RMB439.20 | In Stock |
|
| 50MG | RMB1077.60 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 179.0 to 183.0 °C |
| Boiling point: | 531.7±38.0 °C(Predicted) |
| Density | 1.388 |
| storage temp. | 2-8°C |
| solubility | Soluble in dimethyl sulfoxide, ethanol and dimethyl formamide. |
| form | powder |
| pka | 16.12±0.40(Predicted) |
| color | white to beige |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months |
| InChI | InChI=1S/C13H13ClN2O/c14-7-4-5-11-10(6-7)8-2-1-3-9(13(15)17)12(8)16-11/h4-6,9,16H,1-3H2,(H2,15,17) |
| InChIKey | FUZYTVDVLBBXDL-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(Cl)C=C2)C2=C1C(C(N)=O)CCC2 |
Description and Uses
EX-527 (49843-98-3) is a selective SIRT1 inhibitor (IC50=98 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage. Cell permeable.
A selective inhibitor of SIRT1 over SIRT2 and SIRT3
Safety
| Symbol(GHS) |   GHS07,GHS06 |
| Signal word | Danger |
| Hazard statements | H301-H319-H302 |
| Precautionary statements | P301+P310-P305+P351+P338-P264-P280i-P301+P312a-P337+P313-P501a |
| Hazard Codes | Xn |
| Risk Statements | 22-36 |
| Safety Statements | 26 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | 3 |
| HS Code | 2933998090 |
