SRT1720 , ≥98% , 1001645-58-4

Synonym(s):
InSolution SRT1720, HCl - CAS 1001645-58-4 - Calbiochem

CAS NO.：1001645-58-4

Empirical Formula: C25H24ClN7OS

Molecular Weight: 506.022

MDL number: MFCD18074509

PRODUCT Properties

• Melting point: >205°C (dec.)
• Density: 1.58
• storage temp.: = -70C
• solubility: Soluble in DMSO (>25 mg/ml)
• form: Liquid
• color: White
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• InChIKey: DTGRRMPPXCRRIM-UHFFFAOYSA-N
• SMILES: C(N1CCNCC1)C1=CSC2=NC(C3C=CC=CC=3NC(C3C=NC4C=CC=CC=4N=3)=O)=CN12.Cl

Description and Uses

SRT1720 (1001645-58-4) is a SIRT1 activator (EC1.5 = 0.16 μM, max activation = 781%).1 It reduced glucose levels and hyperinsulinemia in DIO, Lepob/ob mice and Zucker fa/fa rats.? SRT1720 enhanced endurance running and protected against diet-induced obesity and insulin resistance via enhancement of oxidative metabolism in skeletal muscle, liver, and brown adipose tissue.2 It induced mitochondrial biogenesis in oxidant-induced renal proximal tube cell injury.3 SRT1720 repressed circadian clock gene expression and decreased H3 K9/K14 acetylation in a time-specific manner.4 It attenuated angiotensin II-induced atherosclerosis by inhibiting the vascular inflammatory response.5

SRT1720 acts as a therapeutic in the treatment of type 2 diabetes. It modulates calories and contributes to glucose homeostasis and insulin sensitivity.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P280-P301+P312-P302+P352-P305+P351+P338