Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate , 97% , 161797-99-5

CAS NO.：161797-99-5

Empirical Formula: C13H13NO3S

Molecular Weight: 263.31

MDL number: MFCD03700424

EINECS: 605-268-8

PRODUCT Properties

• Melting point: 180 ºC
• Boiling point: 426.8±55.0 °C(Predicted)
• Density: 1.274
• storage temp.: Sealed in dry,Room Temperature
• solubility: DMSO (Slightly), Methanol (Very Slightly)
• form: Solid
• pka: 8.56±0.15(Predicted)
• color: Off-White
• InChI: InChI=1S/C13H13NO3S/c1-3-17-13(16)11-8(2)14-12(18-11)9-4-6-10(15)7-5-9/h4-7,15H,3H2,1-2H3
• InChIKey: LOCYSKNNFCGDTR-UHFFFAOYSA-N
• SMILES: S1C(C(OCC)=O)=C(C)N=C1C1=CC=C(O)C=C1
• CAS DataBase Reference: 161797-99-5(CAS DataBase Reference)

Description and Uses

Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a