PRODUCT Properties
| Boiling point: | 148-151 °C(lit.) |
| Density | 0.903 g/mL at 25 °C(lit.) |
| refractive index | n |
| Flash point: | 85 °F |
| storage temp. | 2-8°C |
| form | clear liquid |
| color | Colorless to Light orange to Yellow |
| λmax | 224nm(EtOH)(lit.) |
| InChI | 1S/C8H10/c1-2-8-6-4-3-5-7-8/h1,6H,3-5,7H2 |
| InChIKey | DKFHWNGVMWFBJE-UHFFFAOYSA-N |
| SMILES | C#CC1=CCCCC1 |
| EPA Substance Registry System | Cyclohexene, 1-ethynyl- (931-49-7) |
Description and Uses
1-ETHYNYLCYCLOHEXENE can be used to prepare 4-phenoxyquinoline-N-sulfonylamidine compounds with the following structure. These compounds can act as tyrosine kinase inhibitors, especially c-Met inhibitors. c-Met is highly expressed in most solid tumors and some sarcomas and is closely associated with poor prognosis, such as lung cancer, breast cancer, colon cancer, prostate cancer, liver cancer, gastric cancer, and glioma. Furthermore, patients with high HGF/c-Met expression levels have stronger resistance to chemotherapy and radiotherapy. Besides abnormal HGF/c-Met expression, c-Met can also be activated in cancer patients through gene mutation and gene amplification.
Safety
| Symbol(GHS) |   GHS02,GHS07 |
| Signal word | Warning |
| Hazard statements | H226-H315-H319-H335 |
| Precautionary statements | P210-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter |
| Hazard Codes | Xi |
| Risk Statements | 10-36/37/38 |
| Safety Statements | 16-26-36/37/39 |
| RIDADR | UN 3295 3/PG 3 |
| WGK Germany | 3 |
| HazardClass | 3.2 |
| PackingGroup | III |
| HS Code | 2902110000 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Eye Irrit. 2 Flam. Liq. 3 Skin Irrit. 2 STOT SE 3 |
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
