Fmoc chloride , 98% , 28920-43-6
Synonym(s):
Fmoc-Cl;9-Fluorenylmethyl chloroformate;9-Fluorenylmethoxycarbonyl chloride;Chloroformic acid 9-fluorenylmethyl ester, FMOCCl;(9-Fluorenylmethyl) chloroformate
CAS NO.：28920-43-6
Empirical Formula: C15H11ClO2
Molecular Weight: 258.7
MDL number: MFCD00001138
EINECS: 249-313-6
| Pack Size | Price | Stock | Quantity |
| 1g | RMB23.20 | In Stock |
|
| 5G | RMB24.00 | In Stock |
|
| 25G | RMB64.00 | In Stock |
|
| 100G | RMB191.20 | In Stock |
|
| 500G | RMB910.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 62-64 °C(lit.) |
| Boiling point: | 365.79°C (rough estimate) |
| Density | 1.1780 (rough estimate) |
| refractive index | 1.5330 (estimate) |
| storage temp. | 2-8°C |
| solubility | dioxane: 0.1 g/mL, clear, colorless |
| form | Crystalline Powder |
| color | White to very pale yellow |
| Sensitive | Moisture Sensitive |
| BRN | 2279177 |
| Stability: | Hygroscopic, Moisture Sensitive |
| InChI | InChI=1S/C15H11ClO2/c16-15(17)18-9-14-12-7-3-1-5-10(12)11-6-2-4-8-13(11)14/h1-8,14H,9H2 |
| InChIKey | IRXSLJNXXZKURP-UHFFFAOYSA-N |
| SMILES | C(Cl)(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O |
| LogP | 3.45 |
| CAS DataBase Reference | 28920-43-6(CAS DataBase Reference) |
Description and Uses
9-Fluorenylmethyl chloroformate (Fmoc-C1) is a significant biochemical reagent introduced by Carpino. It has been widely utilized as a reagent for the introduction of the 9-fluorenylmethoxycarbonyl (Fmoc moiety) in both peptide and nucleotide synthesis, as well as serving as a coupling agent in peptide synthesis[1]. Furthermore, Fmoc-C1 can function as a versatile fluorescent labeling reagent for primary and secondary amines[2].
9-Fluorenylmethyl chloroformate can be used as N-protecting reagent for oligonucleotide and peptide syntheses. It can act as reagent for the introduction of Fmoc-amino-protecting group, which is stable towards acids but is readily cleaved under mildly basic non-hydrolytic conditions.
Safety
| Symbol(GHS) |  GHS05 |
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
| Hazard Codes | C,T |
| Risk Statements | 34-20/21/22 |
| Safety Statements | 26-36/37/39-45-27 |
| RIDADR | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| RTECS | LQ6250000 |
| F | 10-21 |
| TSCA | No |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29159020 |
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) |
