Felodipine , ≥98.0% , 72509-76-3

Synonym(s):
4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester;Plendil

CAS NO.：72509-76-3

Empirical Formula: C18H19Cl2NO4

Molecular Weight: 384.25

MDL number: MFCD08235033

EINECS: 620-472-7

PRODUCT Properties

• Melting point: 142-145°C
• Boiling point: 471.5±45.0 °C(Predicted)
• Density: 1.3506 (rough estimate)
• refractive index: 1.6500 (estimate)
• storage temp.: 2-8°C
• solubility: DMSO: 28 mg/mL
• form: solid
• pka: 2.73±0.70(Predicted)
• color: light yellow
• Water Solubility: insoluble
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
• Major Application: pharmaceutical; pharmaceutical small molecule
• InChI: InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
• InChIKey: RZTAMFZIAATZDJ-UHFFFAOYSA-N
• SMILES: C1(C)NC(C)=C(C(OC)=O)C(C2=CC=CC(Cl)=C2Cl)C=1C(OCC)=O
• CAS DataBase Reference: 72509-76-3(CAS DataBase Reference)
• NIST Chemistry Reference: Felodipine(72509-76-3)

Description and Uses

Felodipine is a vasodilatory calcium antagonist with a high degree of vascular selectivity. It is currently indicated for use only in hypertension, either as monotherapy or in conjunction with diuretics or beta blockers.

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Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn
• Risk Statements: 22
• Safety Statements: 36
• RIDADR: UN 3077 9 / PGIII
• WGK Germany: 3
• RTECS: US7968700
• HS Code: 29333990
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Acute Tox. 4 Oral; Aquatic Acute 1; Aquatic Chronic 1; Repr. 2; STOT RE 2 Inhalation