Fexofenadine HCl , ≥98% , 153439-40-8

Synonym(s):
Fexofenidine hydrochloride;MDL 16455 hydrochloride;Terfenidine carboxylate hydrochloride

CAS NO.：153439-40-8

Empirical Formula: C32H40ClNO4

Molecular Weight: 538.13

MDL number: MFCD08064193

EINECS: 604-906-2

PRODUCT Properties

• Melting point: 148-150oC
• RTECS: CY1633377
• storage temp.: 2-8°C
• solubility: Soluble in Dimethyl sulfoxide (50 mM), and methanol.
• form: powder
• color: white to beige
• Merck: 14,4068
• InChIKey: RRJFVPUCXDGFJB-UHFFFAOYSA-N
• SMILES: C(C1C=CC=CC=1)(C1C=CC=CC=1)(C1CCN(CCCC(C2C=CC(C(C)(C)C(=O)O)=CC=2)O)CC1)O.Cl
• CAS DataBase Reference: 153439-40-8(CAS DataBase Reference)

Description and Uses

Fexofenadine is a histamine H₁ receptor antagonist (K_i = 10 nM). It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine . Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells. Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium (DSS; ).

Fexofenadine is a non-sedating antihistamine that selectively antagonizes the histamine H1 receptor with a Ki value of 10 nM and exhibits anti-inflammatory effects. It is devoid of central nervous system effects in part because it is a good substrate for the P-glycoprotein efflux pump situated within the blood-brain barrier.[Cayman Chemical]

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Warning
• Hazard statements: H317-H360-H312
• Precautionary statements: P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P280-P302+P352-P312-P322-P363-P501
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• HS Code: 2933399090