Loratadine , ≥98% , 79794-75-5

Synonym(s):
4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester;Loratadine;Loratidine

CAS NO.：79794-75-5

Empirical Formula: C22H23ClN2O2

Molecular Weight: 382.88

MDL number: MFCD00672869

EINECS: 1308068-626-2

PRODUCT Properties

• Melting point: 134-136°C
• Boiling point: 531.3±50.0 °C(Predicted)
• Density: 1.261±0.06 g/cm3(Predicted)
• RTECS: TM6129200
• storage temp.: 2-8°C
• solubility: DMSO: 26 mg/mL, soluble
• form: powder
• pka: 4.27±0.20(Predicted)
• color: white
• Water Solubility: It is soluble in DMSO (50 mg/ml), ethanol (77 mg/ml at 25°C), water (<1 mg/ml at 25°C), chloroform, and methanol.
• Merck: 14,5578
• BCS Class: 2
• Stability: Stable, but may be heat sensitive - refrigerate. Incompatible with strong oxidizing agents.
• InChIKey: JCCNYMKQOSZNPW-UHFFFAOYSA-N
• CAS DataBase Reference: 79794-75-5(CAS DataBase Reference)
• EPA Substance Registry System: 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester (79794-75-5)

Description and Uses

Loratadine is a non-sedating antihistamine indicated for use in allergic rhinitis and chronic urticaria. Its major advantage over other non-sedating antihistamines such as astemizole and terfenadine is its very fast onset of action. Loratadine is claimed not to cross the blood-brain barrier.

Histamine H1 receptor antagonist; antihistamine.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H319-H335-H315
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 22-24/25-36-26
• RIDADR: 3077
• WGK Germany: 2
• HS Code: 29333990
• Hazardous Substances Data: 79794-75-5(Hazardous Substances Data)