1-(2-fluoro-benzyl)-1h-pyrazolo[3,4-b]pyridine-3-carboxamidine hydrochloride , 97% , 256499-19-1

CAS NO.：256499-19-1

Empirical Formula: C14H13ClFN5

Molecular Weight: 305.738

MDL number: MFCD18432772

EINECS: 1592732-453-0

PRODUCT Properties

• Melting point: 247-249oC
• storage temp.: Inert atmosphere,Room Temperature
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• color: White
• InChI: InChI=1S/C14H12FN5.ClH/c15-11-6-2-1-4-9(11)8-20-14-10(5-3-7-18-14)12(19-20)13(16)17;/h1-7H,8H2,(H3,16,17);1H
• InChIKey: DQASIYVADJWVLY-UHFFFAOYSA-N
• SMILES: C(C1C=CC=CC=1F)N1N=C(C(N)=N)C2C=CC=NC1=2.Cl

Description and Uses

1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide Hydrochloride is a key intermediate in the synthesis of Riociguat, a potent, oral stimulator of soluble guanylate cyclase for the treatment of pulmonary hypertension.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338