Glutathione (Reduced) , 98% , 70-18-8

Synonym(s):
GSH;Glutathione (reduced);Glutathione, Reduced, Free Acid - CAS 70-18-8 - Calbiochem;γ-L-Glutamyl-L-cysteinyl-glycine;γ-Glu-Cys-Gly, GSH

CAS NO.：70-18-8

Empirical Formula: C10H17N3O6S

Molecular Weight: 307.32

MDL number: MFCD00065939

EINECS: 200-725-4

PRODUCT Properties

• Melting point: 192-195 °C (dec.) (lit.)
• Boiling point: 754.5±60.0 °C(Predicted)
• alpha: -16.5 º (c=2, H2O)
• Density: 1.4482 (rough estimate)
• bulk density: 160kg/m3
• refractive index: -17 ° (C=2, H2O)
• storage temp.: 2-8°C
• solubility: H₂O: 50 mg/mL
• form: powder
• pka: pK1 2.12; pK2 3.53; pK3 8.66; pK4 9.12(at 25℃)
• color: White
• PH: 3 (10g/l, H2O, 20°C)
• Odor: Odorless
• optical activity: -21.327 (H2O)
• Water Solubility: soluble
• Merck: 14,4475
• BRN: 1729812
• Sequence: H-γ-Glu-Cys-Gly-OH
• Stability: Stable. Incompatible with strong oxidizing agents.
• InChIKey: RWSXRVCMGQZWBV-WDSKDSINSA-N
• LogP: -1.645 (est)
• CAS DataBase Reference: 70-18-8(CAS DataBase Reference)
• EPA Substance Registry System: Glutathione (70-18-8)

Description and Uses

Glutathione (GSH) is a tripeptide (γ-glutamylcysteinylglycine) widely distributed in both plants and animals. GSH serves as a nucleophilic co-substrate to glutathione transferases in the detoxification of xenobiotics and is an essential electron donor to glutathione peroxidases in the reduction of hydroperoxides. GSH is also involved in amino acid transport and maintenance of protein sulfhydryl reduction status. The concentration of GSH ranges from a few micromolar in plasma to several millimolar in tissues such as liver.

glutathione is a peptide composed of cysteine, glycine, and glutamate. It is believed to enhance the skin’s cellular metabolism and oxygen utilization. It has been found to protect the fibroblast against free radical-induced oxidation and act as a powerful antioxidant. Studies indicate that it can inactivate the tyrosinase enzyme and quench free radicals that contribute to tyrosinase and melanin formation, thereby serving as a skin-lightening or de- pigmenting agent. glutathione is a component of plant and animal tissue, naturally occurring in the body and essential for the proper functioning of the immune system.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 68-36/37/38
• Safety Statements: 24/25-36/37/39-27-26
• WGK Germany: 2
• RTECS: MC0556000
• F: 9-23
• TSCA: Yes
• HS Code: 29309070