Glyburide , ≥99% , 10238-21-8

Synonym(s):
5-Chloro-N-[4-(cyclohexylureidosulfonyl)phenethyl]-2-methoxybenzamide;Glybenclamide;Glyburide;Glyburide - CAS 10238-21-8 - Calbiochem;N-p-[2-(5-Chloro-2-methoxybenzamido)ethyl]benzenesulfonyl-N′-cyclohexylurea

CAS NO.：10238-21-8

Empirical Formula: C23H28ClN3O5S

Molecular Weight: 494

MDL number: MFCD00056625

EINECS: 233-570-6

PRODUCT Properties

• Melting point: 173-175°C
• Density: 1.1805 (rough estimate)
• refractive index: 1.6100 (estimate)
• storage temp.: 2-8°C
• solubility: ethanol: soluble2mg/mL
• form: White solid
• pka: 5.3(at 25℃)
• color: White
• Water Solubility: Soluble in ethanol (5 mg/mL), DMSO (25 mg/mL), chloroform (1:36), methanol (1:250), and DMF. Insoluble in water.
• Merck: 14,4478
• BCS Class: 2
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
• InChIKey: ZNNLBTZKUZBEKO-UHFFFAOYSA-N
• CAS DataBase Reference: 10238-21-8(CAS DataBase Reference)
• NIST Chemistry Reference: Glyburide(10238-21-8)
• EPA Substance Registry System: Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy- (10238-21-8)

Description and Uses

Glyburide (10238-21-8) is a second generation oral hypoglycemic agent. Acts via ATP-dependent K+ channel (Kir6, KATP) block.1?Inhibits Kir6 currents in the pancreas, causing an increase in intracellular Ca2+ and insulin secretion. Glyburide also inhibits recombinant CFTR Cl- channels with an IC50 of 20 μM.2?Cell permeable.

An ATP-dependent KIR6 and CFTR Cl- channel blocker

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H370
• Precautionary statements: P260-P264-P270-P308+P311-P405-P501
• Hazard Codes: Xn
• Risk Statements: 20/21/22
• Safety Statements: 22-36/37/39-36-24/25
• WGK Germany: 2
• RTECS: YS4725200
• HS Code: 29350090
• Toxicity: LD50 in rats and mice (g/kg): >20 orally; >12.5 i.p.; >20 s.c. (Mizukami)