A4709212
(S)-3-Hydroxytetrahydrofuran , 98% , 86087-23-2
Synonym(s):
(S)-(+)-Tetrahydro-3-furanol
CAS NO.：86087-23-2
Empirical Formula: C4H8O2
Molecular Weight: 88.11
MDL number: MFCD00064327
EINECS: 1308068-626-2
| Pack Size | Price | Stock | Quantity |
| 1G | RMB24.00 | In Stock |
|
| 5G | RMB33.60 | In Stock |
|
| 25G | RMB114.40 | In Stock |
|
| 100g | RMB443.20 | In Stock |
|
| 500g | RMB2043.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| alpha | 18.5 º (c=2 MeOH) |
| Boiling point: | 80 °C/15 mmHg (lit.) |
| Density | 1.103 g/mL at 25 °C (lit.) |
| vapor pressure | 47Pa at 25℃ |
| refractive index | n |
| Flash point: | 175 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol (Slightly) |
| form | Liquid |
| pka | 14.49±0.20(Predicted) |
| color | Clear colorless to pale yellow |
| Specific Gravity | 1.11 |
| optical activity | [α]20/D +17.5°, c = 2.4 in methanol |
| Water Solubility | soluble |
| BRN | 4652609 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChI | 1S/C4H8O2/c5-4-1-2-6-3-4/h4-5H,1-3H2/t4-/m0/s1 |
| InChIKey | XDPCNPCKDGQBAN-BYPYZUCNSA-N |
| SMILES | O[C@H]1CCOC1 |
| LogP | -0.784 at 22℃ and pH6.8 |
| Surface tension | 72mN/m at 1g/L and 25℃ |
| CAS DataBase Reference | 86087-23-2(CAS DataBase Reference) |
Description and Uses
(S)-(+)-3-Hydroxytetrahydrofuran (3-OH THF) is a colorless liquid with a normal boiling point of 179 °C and boiling at 88-89 °C at 17 mmHg, with density (1.087 g/cm3 at 19 °C). 3-OH THF is a useful pharmaceutical intermediate. The chiral (absolute configuration S) version of this compound is an intermediate to launched retroviral drugs.
(S)-(+)-3-Hydroxytetrahydrofuran is an intermediate to the AIDS drugs amprenavir and fosamprenavir. Additionally, it has been an intermediate to developmental drug substances, such as chemotherapy agents.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| target organs | Respiratory system |
| PPE | Eyeshields, Gloves, type ABEK (EN14387) respirator filter |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39 |
| RIDADR | NA 1993 / PGIII |
| WGK Germany | 3 |
| HS Code | 29321900 |
| Storage Class | 10 - Combustible liquids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
