Hypoxanthine , 99% , 68-94-0
Synonym(s):
6-Hydroxypurine;Hypoxanthine;Hypoxanthine - CAS 68-94-0 - Calbiochem
CAS NO.：68-94-0
Empirical Formula: C5H4N4O
Molecular Weight: 136.11
MDL number: MFCD00005725
EINECS: 200-697-3
| Pack Size | Price | Stock | Quantity |
| 5G | RMB24.00 | In Stock |
|
| 25G | RMB39.20 | In Stock |
|
| 100G | RMB90.40 | In Stock |
|
| 500g | RMB352.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >300 °C (lit.) |
| Boiling point: | 250.36°C (rough estimate) |
| Density | 1.4295 (rough estimate) |
| refractive index | 1.8500 (estimate) |
| storage temp. | 2-8°C |
| solubility | 1 M NaOH: 25 mg/mL |
| form | powder |
| pka | 8.7(at 25℃) |
| color | Colorless to yellow to brown, darken on storage with no loss of purity |
| Odor | Odorless |
| biological source | synthetic (organic) |
| Water Solubility | practically insoluble |
| Merck | 14,4869 |
| BRN | 5811 |
| InChI | 1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10) |
| InChIKey | FDGQSTZJBFJUBT-UHFFFAOYSA-N |
| SMILES | O=C1NC=Nc2nc[nH]c12 |
| LogP | -0.910 (est) |
| CAS DataBase Reference | 68-94-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Hypoxanthine(68-94-0) |
| EPA Substance Registry System | Hypoxanthine (68-94-0) |
Description and Uses
Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid. It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia. Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.
Hypoxanthine is a nutrient additive for a variety of cell culture applications involving bacterial, parasite (Plasmodium falciparum) and animal cells. Hypoxanthine is a component of selection media used in hybridoma technologies.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264b-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P330-P362+P364-P403+P233-P501c |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-22-40 |
| Safety Statements | 22-24/25-37/39-26-36 |
| WGK Germany | 3 |
| RTECS | UP0791000 |
| Hazard Note | Harmful |
| TSCA | TSCA listed |
| HS Code | 29335990 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | LD50 intraperitoneal in mouse: 750mg/kg |
