HATU , 99% , 148893-10-1

Synonym(s):
N-[(Dimethylamino)-1H-1,2,3-triazolo-[4,5-b]pyridin-1-ylmethylene]-N-methylmethanaminium hexafluorophosphate N-oxide;1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate;HATU

CAS NO.：148893-10-1

Empirical Formula: C10H15F6N6OP

Molecular Weight: 380.24

MDL number: MFCD00274639

EINECS: 604-662-7

PRODUCT Properties

• Melting point: 183-188 °C (dec.)
• RTECS: XZ5633000
• storage temp.: 2-8°C
• solubility: >16mg/mL in DMSO
• form: powder to crystaline
• color: White to Almost white
• Water Solubility: Soluble in acetonitrile. Insoluble in water.
• InChI: InChI=1S/C10H15N6O.F6P/c1-13(2)10(14(3)4)15-8-6-5-7-11-9(8)16(17)12-15;1-7(2,3,4,5)6/h5-7H,1-4H3;/q+1;-1
• InChIKey: KZAWCZZRROLLDL-UHFFFAOYSA-N
• SMILES: [P+5]([F-])([F-])([F-])([F-])([F-])[F-].C(=[N+]1/N=N(=O)C2=NC=CC=C/12)(\N(C)C)/N(C)C
• CAS DataBase Reference: 148893-10-1(CAS DataBase Reference)
• EPA Substance Registry System: 1H-1,2,3-Triazolo[4,5-b]pyridinium, 1-[bis(dimethylamino)methylene]-, hexafluorophosphate(1-), 3-oxide (148893-10-1)

Description and Uses

HATU, first prepared by Louis A. Carpino in 1993, is widely used in carboxylic acid amidation reactions. It acts as a facilitator of amide bond generation by activating the carboxyl group.

HATU[148893-10-1] is a coupling reagent and used as an additive in peptide synthesis. It is also involved efficiently to speed up the coupling process and reduces the loss of chiral integrity.
Reagent for: Synthesis of Aurora A kinase inhibitors, HPLC assay to determine D- and L- acid enantiomers in human plasma, Amide bond formation reactions.
Catalyst for: Selective acylation, Selecocyclization-oxidation deselenation sequence.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H317-H334
• Precautionary statements: P261-P272-P280-P284-P302+P352-P304+P340+P312
• Hazard Codes: Xi,Xn,E
• Risk Statements: 36/37/38-20/21/22-2
• Safety Statements: 26-37/39-36/37-36-35
• RIDADR: 1325
• WGK Germany: 3
• F: 10-21
• HazardClass: 4.1
• PackingGroup: Ⅱ
• HS Code: 29339999