A4722412
HEPPS , ≥99.5%(T) , 16052-06-5
Synonym(s):
N-(2-Hydroxyethyl)piperazine-N′-(3-propanesulfonic acid);4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid;4-(2-Hydroxyethyl)piperazine-1-propanesulfonic acid;HEPPS
CAS NO.：16052-06-5
Empirical Formula: C9H20N2O4S
Molecular Weight: 252.33
MDL number: MFCD00006160
EINECS: 240-198-8
| Pack Size | Price | Stock | Quantity |
| 25G | RMB77.60 | In Stock |
|
| 100G | RMB239.20 | In Stock |
|
| 500G | RMB1048.00 | In Stock |
|
| 2.5kg | RMB4799.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 237-239 °C(lit.) |
| Density | 1.2684 (rough estimate) |
| refractive index | 1.6800 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | H2O: 1 M at 20 °C, clear, colorless |
| form | Powder/Solid |
| color | White |
| PH | 5.0-6.5 (25℃, 0.1M in H2O) |
| pka | 8.0(at 25℃) |
| PH Range | 7.3 - 8.7 |
| Water Solubility | Soluble in water. 25.2 g/L (20°C) |
| λmax | λ: 260 nm Amax: 0.055 λ: 280 nm Amax: 0.045 |
| BRN | 3957385 |
| Major Application | diagnostic assay manufacturing |
| InChI | 1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15) |
| InChIKey | OWXMKDGYPWMGEB-UHFFFAOYSA-N |
| SMILES | OCCN1CCN(CCCS(O)(=O)=O)CC1 |
| CAS DataBase Reference | 16052-06-5(CAS DataBase Reference) |
| EPA Substance Registry System | 1-Piperazinepropanesulfonic acid, 4-(2-hydroxyethyl)- (16052-06-5) |
| Absorption | ≤0.1 at 260 in H2O at 1M ≤0.1 at 280 in H2O at 1M |
Description and Uses
HEPPS (EPPS) is a commonly used Good's buffer. It is often used as separator in ultrathin isoelectric focusing gels and enhances the resolution of phosphoglucomutase. It is used as a buffering agent in biology and biochemistry. HEPPS is a biological buffer with a useful pH range of 7.3-8.7 and a pKa=8.0 at 25°C. Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice. HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P280-P305+P351+P338-P310 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38-22 |
| Safety Statements | 24/25-36-26 |
| WGK Germany | 3 |
| RTECS | TM2649130 |
| TSCA | TSCA listed |
| HazardClass | IRRITANT |
| HS Code | 29335995 |
| Storage Class | 11 - Combustible Solids |
| Toxicity | quail,LD50,oral,> 316mg/kg (316mg/kg),Ecotoxicology and Environmental Safety. Vol. 6, Pg. 149, 1982. |
