H₂N-PEG₄-CH₂CH₂COO^tBu , 95% , 581065-95-4

Synonym(s):
tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate;H₂N-dPEG(4)-CO-OtBu;H₂N-PEG₄-CH₂CH₂COOtBu

CAS NO.：581065-95-4

Empirical Formula: C15H31NO6

Molecular Weight: 321.41

MDL number: MFCD11041116

PRODUCT Properties

• Boiling point: 400.1±35.0 °C(Predicted)
• Density: 1.040±0.06 g/cm3(Predicted)
• refractive index: n/D 1.4508
• storage temp.: -20°C
• solubility: Soluble in Water, DMSO, DCM, DMF
• form: clear liquid
• pka: 8.74±0.10(Predicted)
• color: Colorless to Light yellow
• InChI: InChI=1S/C15H31NO6/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h4-13,16H2,1-3H3
• InChIKey: PKESARRNSGIDRD-UHFFFAOYSA-N
• SMILES: C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCN
• CAS DataBase Reference: 581065-95-4

Description and Uses

Amino-PEG4-t-butyl ester is a PEG reagent containing an amino (NH2) and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl (Boc) can be deprotected under acidic conditions.

is a linker-cytotoxin conjugate. Linker-cytotoxin conjugate is related to antibody-cytotoxin and antibody-drug conjugates and related compounds.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
• HS Code: 2922190090