Hoveyda-Grubbs Catalyst 1<SUP>st</SUP> Generation , 97% , 203714-71-0

Synonym(s):
Dichloro(o-isopropoxyphenylmethylene)(tricyclohexylphosphine)ruthenium(II);Dichloro(2-isopropoxyphenylmethylene) (tricyclohexylphosphine)ruthenium(II);Hoveyda-Grubbs Catalyst 1st Generation;Hoveyda-Grubbs Catalyst M70 (C601)

CAS NO.：203714-71-0

Empirical Formula: C28H45Cl2OPRu

Molecular Weight: 600.61

MDL number: MFCD03453042

EINECS: 692-988-0

PRODUCT Properties

• Melting point: 195-197 °C(lit.)
• storage temp.: 2-8°C
• solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• form: Solid
• color: Very Dark Purple
• InChI: 1S/C18H33P.C10H12O.2ClH.Ru/c1-4-10-16(11-5-1)19(17-12-6-2-7-13-17)18-14-8-3-9-15-18;1-8(2)11-10-7-5-4-6-9(10)3;;;/h16-18H,1-15H2;3-8H,1-2H3;2*1H;/q;;;;+2/p-2
• InChIKey: KMKCJXPECJFQPQ-UHFFFAOYSA-L
• SMILES: P(C1CCCCC1)(C1CCCCC1)C1CCCCC1.C1(C=[Ru](Cl)Cl)=CC=CC=C1OC(C)C

Description and Uses

Proven to be useful in Ring-Closing Metathesis (RCM) to form macrocycles. Also employed in a pivotal, macrocyclic ring-closing metathesis in the multi-step synthesis of an HCV protease inhibitor.

Safety

• Symbol(GHS): GHS02
• Signal word: Warning
• Hazard statements: H228
• Precautionary statements: P210
• PPE: Eyeshields, Gloves, type N95 (US)
• Hazard Codes: F
• Risk Statements: 11
• RIDADR: UN1325 - class 4.1 - PG 2 - Flammable solids, organic, n.o.s., HI: all
• WGK Germany: 3
• Storage Class: 4.1B - Flammable solid hazardous materials
• Hazard Classifications: Flam. Sol. 2