2'-Deoxy-7,8-dihydro-8-oxoguanosine , ≥95.0%(HPLC) , 88847-89-6

Synonym(s):
8-Oxo-7,8-dihydro-2′-deoxyguanosine;8-Oxo-dG

CAS NO.：88847-89-6

Empirical Formula: C10H13N5O5

Molecular Weight: 283.24

MDL number: MFCD00210311

PRODUCT Properties

• Melting point: 217-220°C
• Density: 2.25±0.1 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: Soluble in DMSO (up to 10 mg/ml).
• pka: 7.86±0.20(Predicted)
• form: White to off-white solid.
• color: Off-white
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
• InChI: InChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1
• InChIKey: HCAJQHYUCKICQH-VPENINKCSA-N
• SMILES: OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)NC2=O)C[C@@H]1O

Description and Uses

8-Oxo-2′-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes.1?It is a critical biomarker for oxidative stress and carcinogenesis.2,3

8-Hydroxy-2′-deoxyguanosine has been used:

• as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection
• as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement
• as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential?antioxidant?activity of green coffee bean extract (GCBE) in vivo
• as a standard for LC/MS/MS analysis

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: MF8782675
• HS Code: 29349990