4'-Hydroxychalcone , >95.0%(HPLC) , 2657-25-2

CAS NO.：2657-25-2

Empirical Formula: C15H12O2

Molecular Weight: 224.25

MDL number: MFCD00016484

PRODUCT Properties

• Melting point: 174-178 °C
• Boiling point: 419.6±45.0 °C(Predicted)
• Density: 1.191±0.06 g/cm3(Predicted)
• storage temp.: Inert atmosphere,Room Temperature
• solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
• form: powder to crystal
• pka: 7.72±0.15(Predicted)
• color: Light orange to Yellow to Green
• BRN: 2049150
• InChI: InChI=1S/C15H12O2/c16-14-9-7-13(8-10-14)15(17)11-6-12-4-2-1-3-5-12/h1-11,16H
• InChIKey: UAHGNXFYLAJDIN-IZZDOVSWSA-N
• SMILES: C(C1=CC=C(O)C=C1)(=O)C=CC1=CC=CC=C1
• LogP: 3.650 (est)
• CAS DataBase Reference: 2657-25-2(CAS DataBase Reference)

Description and Uses

4''-hydroxy Chalcone is a chalcone metabolite with diverse biological activities. It is formed when chalcone is metabolized by the cytochrome (CYP) P450 isoform CYP1A1 or CYP2C6. 4''-hydroxy Chalcone is estrogenic in MCF-7 cells and is cytotoxic at concentrations higher than 100 nM. It inhibits TNF-α-induced NF-κB signaling and the trypsin-, chymotrypsin-, and caspase-like proteolytic activities of the 26S proteasome in K562 cells in a dose-dependent manner. 4''-hydroxy Chalcone reduces growth of K562, U937, and Jurkat cancer cell lines in a dose-dependent manner without effecting viability of peripheral blood mononuclear cells (PBMCs). It also inhibits glutathione reductase (GSH-RD; IC₅₀ = 47.3 μM) in vitro in a reversible and non-competitive manner.

4''-Hydroxychalcone is a chalone derivative that exhibits moderate to good antiviral activity against tobacco mosaic virus (TMV).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 37/39-26-37
• HS Code: 29145090