Indocyanine Green , 75% , 3599-32-4

Synonym(s):
Cardiogreen;Foxgreen;IC Green;Indocyanine green

CAS NO.：3599-32-4

Empirical Formula: C43H49N2NaO6S2

Molecular Weight: 776.98

MDL number: MFCD00013078

EINECS: 222-751-5

PRODUCT Properties

• Melting point: 235 °C
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: H2O: soluble1mg/mL
• form: Powder
• color: Green-bronze
• Appearance: Dark green solid
• Water Solubility: slightly soluble
• ex/em: 786/820nm (Methanol)
• Φ(quantum yield): 0.09
• ε(extinction coefficient): ≥115 at 386-396nm in water; ≥2000 at 774-784nm in water; ≥900 at 712-722nm in water
• Merck: 14,4962
• BRN: 4115884
• InChIKey: JDDBTPDPBRYGPQ-UHFFFAOYSA-N
• SMILES: CC1(C(=[N+](CCCCS([O-])(=O)=O)C2C=CC3=CC=CC=C3C1=2)C=CC=CC=CC=C1C(C2C3=CC=CC=C3C=CC=2N1CCCCS(O)(=O)=O)(C)C)C.[NaH]
• LogP: -0.290
• CAS DataBase Reference: 3599-32-4(CAS DataBase Reference)
• EPA Substance Registry System: 1H-Benz[e]indolium, 2-[7-[1,3-dihydro-1,1-dimethyl-3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]-1,3,5-heptatrienyl]-1,1-dimethyl-3-(4-sulfobutyl)-, inner salt, sodium salt (3599-32-4)

Description and Uses

Indocyanine Green (aka ICG, IC Green, Foxgreen) is used for reliable imaging and flow cytometry. This dye is water-soluble and pH-insensitive. The fluorescence of Indocyanine Green is not visible to the human eye but is readily detected by most imaging systems.

Indocyanine Green binds tightly to plasma proteins and becomes confined to the vascular system. The dye has a half-life of 150 to 180 sec and is removed from circulation exclusively by the liver to bile juice.

Indocyanine Green is used for detection of hepatocyte-like cells, determining cardiac output, hepatic function, liver and gastric blood flow, and for ophthalmic angiography.

A tricarbocyanine type of dye with infrared absorbing properties. Diagnostic aid (blood volume determination, cardiac output, hepatic function). Dyes and metabolites.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-37/39
• WGK Germany: 3
• RTECS: DE3150000
• HS Code: 32129000
• Hazardous Substances Data: 3599-32-4(Hazardous Substances Data)
• Toxicity: LD50 intravenous in mouse: 60mg/kg