KU-0063794 , ≥98% , 938440-64-3

Synonym(s):
mTOR Inhibitor IV, Ku-63794 - CAS 938440-64-3 - Calbiochem;rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morp holinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol;rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol, Ku-0063794, mTOR Inhibitor IV, Ku-63794

CAS NO.：938440-64-3

Empirical Formula: C25H31N5O4

Molecular Weight: 465.54

MDL number: MFCD11977741

PRODUCT Properties

• Boiling point: 694.3±65.0 °C(Predicted)
• Density: 1.248
• storage temp.: 2-8°C
• solubility: DMSO: >2mg/mL (warmed)
• form: powder
• pka: 14.20±0.10(Predicted)
• color: white to beige
• InChIKey: RFSMUFRPPYDYRD-CALCHBBNSA-N

Description and Uses

The mammalian target of rapamycin (mTOR) is a serine-threonine kinase which acts as part of two distinct complexes, TORC1 and TORC2. Both complexes (TORC1/2) play central roles in cell growth, gene expression, angiogenesis, and cell survival. Ku-0063794 is a cell-permeable, selective dual inhibitor of mTORC1 and mTORC2 (IC₅₀ = 10 nM). It does not affect the activity of 76 other protein kinases or seven lipid kinases, including PI3Ks. Ku-0063794 inhibits cell growth by inducing G₁-cell cycle arrest and autophagy, but not apoptosis, and inhibits tumor growth in a xenograft model of renal cell carcinoma (8 mg/kg for 46 days).

Ku 0063794 is a specific mammalian target of rapamycin (mTOR) inhibitor and may be used for the treatment of cancers.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301
• Precautionary statements: P264-P270-P301+P310-P321-P330-P405-P501
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 45
• WGK Germany: 3