A5243912
KT5823 , ≥97%(HPLC) , 126643-37-6
Synonym(s):
KT5823 - CAS 126643-37-6 - Calbiochem;PKG Inhibitor VII
CAS NO.：126643-37-6
Empirical Formula: C29H25N3O5
Molecular Weight: 495.53
MDL number: MFCD09878278
EINECS: 603-150-0
| Pack Size | Price | Stock | Quantity |
| 100μg | RMB1999.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Boiling point: | 629.2±55.0 °C(Predicted) |
| Density | 1.52±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | ethyl acetate: 5 mg/mL |
| form | lyophilized powder |
| pka | -1.01±0.60(Predicted) |
| color | white |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months. |
| InChIKey | XCMSIGRHKNQVBF-UDUFFBJHNA-N |
| SMILES | N12C3=C(C4=C1C1=C(C5=C(N1[C@]1([H])O[C@@]2(C)[C@](C)(C(OOC)=O)C1)C=CC=C5)C1C(=O)N(C)CC=14)C=CC=C3 |&1:10,13,15,r| |
Description and Uses
KT5823 (126643-37-6) is a selective protein kinase G inhibitor (K>i =0.23, 4 and >10 μM for PKG, PKC and PKA respectively.1?Arrests human skin fibroblast cell cycle after the G0/G1 boundary.2 KT5823 abolishes the cGMP-induced relaxation in smooth muscle cells (IC50=60 nM).3?Cell permeable.
KT 5823 is a protein kinase inhibitor shown to increase TSH-induced NIS expression, and thus iodide uptake, in thyroid cells.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P280-P271 |
| Hazard Codes | Xi |
| WGK Germany | 3 |
| F | 10 |
| HS Code | 29349990 |
