LY2109761 , ≥99% , 700874-71-1

CAS NO.：700874-71-1

Empirical Formula: C26H27N5O2

Molecular Weight: 441.52

MDL number: MFCD28142655

PRODUCT Properties

• Boiling point: 640.9±55.0 °C(Predicted)
• Density: 1.34
• storage temp.: Store at -20°C
• solubility: ≥22.1 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
• form: solid
• pka: 6.27±0.10(Predicted)
• color: White to yellow
• InChI: InChI=1S/C26H27N5O2/c1-2-9-27-22(4-1)26-25(24-5-3-11-31(24)29-26)21-8-10-28-23-18-19(6-7-20(21)23)33-17-14-30-12-15-32-16-13-30/h1-2,4,6-10,18H,3,5,11-17H2
• InChIKey: IHLVSLOZUHKNMQ-UHFFFAOYSA-N
• SMILES: N1C2C(=CC=C(OCCN3CCOCC3)C=2)C(C2C(C3=NC=CC=C3)=NN3CCCC3=2)=CC=1

Description and Uses

LY2157299 is a small molecule inhibitor of the TGF-β receptor type 1/type II kinases (IC₅₀ = 69 nM). It has been used to study the role of TGF-β signaling in tumor cell migration and metastasis in pancreatic tumor cell lines where 5 μM of the compound completely disrupts Smad-2 phosphorylation, an immediate downstream target of the kinase activity. It can also suppress radiation-induced inflammatory cytokine signaling and proangiogenic genes, including ID1, in human primary fibrobalsts.

LY 2109761 is a novel transforming growth factor beta receptor type I and type II dual inhibitor that is potentially used to treat and suppress pancreatic cancer.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
• HS Code: 29349990