A5318512
Locostatin , 98%(HPLC) , 90719-30-5
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB503.20 | In Stock |
|
| 50MG | RMB1759.20 | In Stock |
|
| 250mg | RMB5599.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 84-88 °C(lit.) |
| Boiling point: | 351.0±25.0 °C(Predicted) |
| Density | 1.205±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥30mg/mL |
| pka | -1?+-.0.40(Predicted) |
| form | powder |
| color | white to off-white |
| InChI | 1S/C14H15NO3/c1-2-6-13(16)15-12(10-18-14(15)17)9-11-7-4-3-5-8-11/h2-8,12H,9-10H2,1H3/b6-2+/t12-/m0/s1 |
| InChIKey | UTZAFVPPWUIPBH-QSLRECBCSA-N |
| SMILES | C\C=C\C(=O)N1[C@H](COC1=O)Cc2ccccc2 |
Description and Uses
Locostatin (UIC-1005) is a potent RKIP inhibitor. Locostatin binds Raf kinase inhibitor RKIP protein and disrupts the interaction of RKIP with Raf-1 kinase and G protein-coupled receptor kinase 2. Locostatin inhibits cell proliferation and migration. Locostatin can be used to synthesize chemical probes toward PEBP-proteins. Locostatin aggravates thioacetamide (HY-Y0698)-induced acute liver failure in mice [1][2][3].
Safety
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| HS Code | 29349990 |
| Storage Class | 11 - Combustible Solids |
