A5395712
1-Methylpiperidine , 97% , 626-67-5
Synonym(s):
N-Methylpiperidine
CAS NO.：626-67-5
Empirical Formula: C6H13N
Molecular Weight: 99.17
MDL number: MFCD00006491
EINECS: 210-959-9
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | -50 °C |
| Boiling point: | 106-107 °C (lit.) |
| Density | 0.816 g/mL at 25 °C (lit.) |
| vapor pressure | 35.7hPa at 20℃ |
| refractive index | n |
| Flash point: | 38 °F |
| storage temp. | −20°C |
| solubility | Chloroform (Sparingly), Methanol (Slightly) |
| pka | 10.08(at 25℃) |
| form | Liquid |
| color | Clear colorless |
| PH | 12 (100g/l, H2O, 20℃) |
| explosive limit | 1.1-9.9%(V) |
| biological source | synthetic |
| Water Solubility | miscible |
| BRN | 1073 |
| Dielectric constant | 2.5899999999999999 |
| LogP | 1.15 at 25℃ |
| CAS DataBase Reference | 626-67-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Piperidine, 1-methyl-(626-67-5) |
| EPA Substance Registry System | Piperidine, 1-methyl- (626-67-5) |
Description and Uses
This simple piperidine derivative has been obtained from Girgensohnia diptera Bge. It is optically inactive and furnishes a crystalline picrate, m.p. 15 I-2°C and a picrolonate, m.p. 226°C.
Reactant for:
- sp3 C-H Bond activation with ruthenium(II) catalysts and C(3)-alkylation of cyclic amines
- One-pot synthesis of Z-cinnamic acids
Reactant for synthesis of:
- Unsymmetrical ureas
- Antibacterial imidazolium, pyrrolidinium, and piperidinium salts
- C1-C16 segment of goniodomin A via palladium-catalyzed organostannane thioester coupling
- Multi-targeted inhibitors of insulin-like growth factor-1 receptor and members of ErbB-family receptor kinases
Safety
| Symbol(GHS) |    GHS02,GHS05,GHS06 |
| Signal word | Danger |
| Hazard statements | H225-H302+H312-H314-H331-H412 |
| Precautionary statements | P210-P273-P280-P303+P361+P353-P304+P340+P311-P305+P351+P338+P310 |
| Hazard Codes | C,F,T |
| Risk Statements | 11-34-20/22-39/23/24/25-23/24/25-67-22-10-37 |
| Safety Statements | 7-16-26-36/37/39-45-9-33 |
| RIDADR | UN 3286 3/PG 2 |
| WGK Germany | 3 |
| RTECS | TN1225000 |
| F | 3-10 |
| TSCA | Yes |
| HazardClass | 3 |
| PackingGroup | II |
| HS Code | 29333999 |
| Toxicity | LD50 intraperitoneal in mouse: 400mg/kg |
| Limited Quantities | 1.0 L (0.3 gallon) (liquid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) |
