Moclobemide (Ro 111163) , 98% , 71320-77-9

Synonym(s):
4-Chloro-N-[2-(4-morpholinyl)ethyl]benzamide;Aurorix;Moclamine

CAS NO.：71320-77-9

Empirical Formula: C13H17ClN2O2

Molecular Weight: 268.74

MDL number: MFCD00865388

EINECS: 629-727-7

PRODUCT Properties

• Melting point: 137°C
• Boiling point: 447.7±40.0 °C(Predicted)
• Density: 1.206±0.06 g/cm3(Predicted)
• storage temp.: room temp
• solubility: DMSO: >20mg/mL
• pka: 14.26±0.46(Predicted)
• form: solid
• color: white
• Merck: 14,6226
• InChI: InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17)
• InChIKey: YHXISWVBGDMDLQ-UHFFFAOYSA-N
• SMILES: C(NCCN1CCOCC1)(=O)C1=CC=C(Cl)C=C1
• CAS DataBase Reference: 71320-77-9(CAS DataBase Reference)
• NIST Chemistry Reference: Moclobemide(71320-77-9)

Description and Uses

Moclobemide is the first of a new generation of non-hydrazine, reversible MAO-A inhibitors useful in the treatment of depression. Moclobemide is a selective inhibitor of MAO-A, allowing tyramine to be metabolized by MAO-B. In controlled studies, moclobemide was clinically superior to desipramine and showed no cholinergic or cardiovascular side-effects. A metabolite is currently under investigation for treatment of Parkinson’s disease,.

A reversible monoamine oxidase inhibitor.

Safety

• Symbol(GHS): GHS05,GHS07
• Signal word: Danger
• Hazard statements: H302-H315-H318-H335
• Precautionary statements: P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
• Hazard Codes: Xn,T+
• Risk Statements: 22-37/38-41-26/27/28
• Safety Statements: 26-39-45-36/37/39-22
• RIDADR: 3249
• WGK Germany: 2
• RTECS: CV2462000
• HazardClass: 6.1(b)
• PackingGroup: III
• HS Code: 29349990
• Hazardous Substances Data: 71320-77-9(Hazardous Substances Data)
• Toxicity: LD50 in rats (mg/kg): 707 orally (Burkard, Wyss)