6-Maleimidohexanoic Acid , 98%(GC) , 55750-53-3

Synonym(s):
MCA;6-Maleimidocaproic acid;Maleimidocaproic acid;N-Maleoyl-6-aminocaproic acid;2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-hexanoic acid

CAS NO.：55750-53-3

Empirical Formula: C10H13NO4

Molecular Weight: 211.21

MDL number: MFCD00043140

EINECS: 611-311-1

PRODUCT Properties

• Melting point: 86-91 °C
• Boiling point: 407.3±28.0 °C(Predicted)
• Density: 1.285±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO (Slightly), Ethyl Acetate (Slightly)
• form: Powder
• pka: 4.74±0.10(Predicted)
• color: White to pale yellow
• Water Solubility: Soluble in water, methanol, ethanol, dimethyl sulfoxide. Insoluble in ether.
• Sensitive: Moisture Sensitive
• BRN: 1532405
• InChI: InChI=1S/C10H13NO4/c12-8-5-6-9(13)11(8)7-3-1-2-4-10(14)15/h5-6H,1-4,7H2,(H,14,15)
• InChIKey: WOJKKJKETHYEAC-UHFFFAOYSA-N
• SMILES: N1(CCCCCC(O)=O)C(=O)C=CC1=O
• CAS DataBase Reference: 55750-53-3(CAS DataBase Reference)
• EPA Substance Registry System: 1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo- (55750-53-3)

Description and Uses

6-Maleimidocaproic acid contains a maleimide group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

6-Maleimidohexanoic acid is used as a probe for introducing maleimides groups into biomolecules and active pharmaceutical ingredients. Further, it is used with N-hydroxysuccinimide ester as a bifunctional cross-linking reagent. In addition to this, it acts as a probe for thiol groups in membrane proteins.

Safety

• Symbol(GHS): GHS05,GHS07
• Signal word: Danger
• Hazard statements: H315-H318-H335
• Precautionary statements: P280-P302+P352-P305+P351+P338+P310
• Hazard Codes: Xi
• Risk Statements: 36/37/38-41-37/38
• Safety Statements: 26-36-39
• WGK Germany: 3
• F: 10-21
• HS Code: 29251900