(S)-(-)-2-Methyl-CBS-oxazaborolidine , 95% , 112022-81-8

Synonym(s):
α,α-Diphenyl-L-prolinol methylboronic acid cycl-amide ester;(S)-1-Methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2c][1,3,2]oxazaborole;(S)-3,3-Diphenyl-1-methyltetrahydro-3H-pyrrolo[1,2-c][1,3,2]oxazaborole;(S)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole

CAS NO.：112022-81-8

Empirical Formula: C18H20BNO

Molecular Weight: 277.17

MDL number: MFCD00078439

EINECS: 601-150-5

PRODUCT Properties

• Melting point: 115-117°C
• Boiling point: 111 °C
• Density: 0.93 g/mL at 20 °C(lit.)
• refractive index: -68 ° (C=1, MeOH)
• Flash point: 40 °F
• storage temp.: room temp
• pka: 1.02±0.40(Predicted)
• form: Liquid
• color: Colorless to amber
• Water Solubility: Hydrolyzes in water.
• Sensitive: Air & Moisture Sensitive
• BRN: 8492123
• Exposure limits: ACGIH: TWA 20 ppm; OSHA: Ceiling 300 ppm; TWA 200 ppm; NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3)
• InChIKey: VMKAFJQFKBASMU-KRWDZBQOSA-N
• CAS DataBase Reference: 112022-81-8(CAS DataBase Reference)

Description and Uses

(S)-2-Methyl-CBS-oxazaborolidine is used as an oxazaborolidine catalyst. It is also employed in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C2-symmetrical ferrocenyl diols and propargyl alcohols. It is an anhydrous catalyst for 'CBS' reduction reaction.

Safety

• Symbol(GHS): GHS05,GHS07
• Signal word: Danger
• Hazard statements: H302-H318
• Precautionary statements: P280-P301+P312+P330-P305+P351+P338+P310
• Hazard Codes: Xi,Xn,F
• Risk Statements: 36/37/38-67-65-63-48/20-11-19-40
• Safety Statements: 26-62-36/37-33-29-16
• RIDADR: UN 1294 3/PG 2
• WGK Germany: 3
• F: 10-21
• HazardClass: 3
• PackingGroup: II
• HS Code: 29349990
• Limited Quantities: 1.0 L (0.3 gallon) (liquid)
• Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)