Mexiletine HCl , ≥98.0%(HPLC) , 5370-01-4

Synonym(s):
1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride;1-(2,6-Xylyloxy)-2-aminopropane hydrochloride;Mexiletine hydrochloride

CAS NO.：5370-01-4

Empirical Formula: C11H18ClNO

Molecular Weight: 215.72

MDL number: MFCD00216024

EINECS: 226-362-1

PRODUCT Properties

• Melting point: 200-203°C
• Density: 1.12 g/cm3
• storage temp.: 2-8°C
• solubility: ethanol: 50 mg/mL
• form: powder
• pka: 9.0(at 25℃)
• color: white
• λmax: 272nm(MeOH)(lit.)
• Merck: 14,6169
• Stability: Hygroscopic
• InChI: InChI=1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
• InChIKey: NFEIBWMZVIVJLQ-UHFFFAOYSA-N
• SMILES: C1(OCC(N)C)=C(C)C=CC=C1C.Cl
• CAS DataBase Reference: 5370-01-4(CAS DataBase Reference)

Description and Uses

Mexiletine is a voltage-gated sodium channel blocker and class Ib antiarrhythmic agent that preferentially binds to open/inactive channels. It inhibits aconitine-induced dysrhythmias in mice with ED₅₀ values of 57 and 107 mg/kg for intraperitoneal and oral administration, respectively. Mexiletine decreases or inhibits conduction across the Purkinje fiber-muscle junction, shortens action potential duration, and decreases the refractory period when used at concentrations less than 5 μg/ml in isolated canine Purkinje fiber and ventricular muscle preparations.

antipsychotic

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn
• Risk Statements: 20/21/22-36/37/38-22
• Safety Statements: 36-26
• WGK Germany: 3
• RTECS: KR9300000
• HS Code: 2922190900
• Toxicity: LD50 in male, female rats, mice, rabbits (mg/kg): 350, 400, 310, 400, 180, 160 orally; in male, female rats, mice (mg/kg): 27, 30, 43, 50 i.v. (Kast)