2′-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid sodium salt hydrate , ≥95%(HPLC) , 76204-02-9

CAS NO.：76204-02-9

Empirical Formula: C21H26NNaO11

Molecular Weight: 491.42

MDL number: MFCD00057309

EINECS: 1533716-785-6

PRODUCT Properties

• Melting point: 171°C dec.
• storage temp.: −20°C
• solubility: H₂O: 50 mg/mL, clear, very slightly yellow
• form: Solid
• color: White to Off-White
• Water Solubility: water: 50mg/mL, clear to slightly hazy, colorless to light yellow
• InChIKey: NSQMRVBWXQQIKF-NVRWCLOTSA-M
• SMILES: O.[H]C(O)(CO)[C@]([H])(O)[C@@H]1OC(C[C@H](O)[C@H]1NC(C)=O)(Oc2ccc3C(C)=CC(=O)Oc3c2)C(=O)O[Na]

Description and Uses

4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is a fluorogenic substrate of neuraminidases. 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid is cleaved by neuraminidases to release the fluorescence moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nm, increasing as pH decreases. 4-Methylumbelliferyl-N-acetyl-α-D-neuraminic acid has been used to quantify neuraminidase activity in mammalian cells and clinical isolates of influenza virus.

(4-Methylumbelliferyl)-N-acetyl-α-D-neuraminic acid sodium salt has been used for fluorometric assay of neuraminidase as well as fluorescent staining of sialidases in PAGE.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P271-P280
• PPE: Eyeshields, Gloves, type N95 (US)
• Safety Statements: 24/25
• WGK Germany: 3
• F: 3-10
• HS Code: 29322090
• Storage Class: 11 - Combustible Solids