4-methylthiazole-5-carboxylic acid , ≥97.0%(GC) , 20485-41-0

Synonym(s):
4-Methyl-1,3-thiazole-5-carboxylic acid

CAS NO.：20485-41-0

Empirical Formula: C5H5NO2S

Molecular Weight: 143.16

MDL number: MFCD00626872

EINECS: 606-565-5

PRODUCT Properties

• Melting point: 287 °C (dec.) (lit.)
• Boiling point: 303.6±22.0 °C(Predicted)
• Density: 1.338 (estimate)
• refractive index: 1.5480 (estimate)
• storage temp.: Keep in dark place,Sealed in dry,Room Temperature
• solubility: DMSO
• form: solid
• pka: 1.16±0.31(Predicted)
• color: Off-White
• InChI: 1S/C5H5NO2S/c1-3-4(5(7)8)9-2-6-3/h2H,1H3,(H,7,8)
• InChIKey: ZGWGSEUMABQEMD-UHFFFAOYSA-N
• SMILES: Cc1ncsc1C(O)=O
• CAS DataBase Reference: 20485-41-0(CAS DataBase Reference)

Description and Uses

4-Methylthiazole-5-carboxylic acid is used as a reagent to synthesize thiazolylimidazolidinone compounds that act as Stearoyl-CoA desaturase-1 (SCD1) inhibitors. These SCD1 inhibitors are used in the treatment of metabolic diseases. 4-Methylthiazole-5-carboxylic acid is also used as a reagent to synthesize 4-Methyl-5-formylthiazole, an important intermediate in the synthesis of Cefditoren pivoxil (C242700).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H317
• Precautionary statements: P280
• PPE: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• Hazard Codes: Xi
• Risk Statements: 43-36/37/38
• Safety Statements: 37/39-26
• WGK Germany: 3
• RTECS: XJ3680000
• HazardClass: IRRITANT
• HS Code: 29341000
• Storage Class: 11 - Combustible Solids
• Hazard Classifications: Skin Sens. 1