N<SUB>3</SUB>-PEG<SUB>4</SUB>-CH<SUB>2</SUB>CH<SUB>2</SUB>COO<SUP>t</SUP>Bu , 97% , 581066-04-8

CAS NO.：581066-04-8

Empirical Formula: C15H29N3O6

Molecular Weight: 347.407

MDL number: MFCD18916988

PRODUCT Properties

• refractive index: 1.449 (589.3 nm 23℃)
• storage temp.: Storage temp. 2-8°C
• form: Liquid
• color: Colorless to light yellow

Description and Uses

Azido-PEG4-t-butyl ester is a click chemistry linker containing an azide (N3) and a t-butyl ester moiety. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group is reactive toward alkyne, BCN, DBCO via Click Chemistry . The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Azido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501