Nifedipine , ≥98.0%(HPLC) , 21829-25-4

Synonym(s):
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester;L-Type Calcium Channel Blocker III;Nifedipine;Nifedipine - CAS 21829-25-4 - Calbiochem

CAS NO.：21829-25-4

Empirical Formula: C17H18N2O6

Molecular Weight: 346.33

MDL number: MFCD00057326

EINECS: 244-598-3

PRODUCT Properties

• Melting point: 171-175 °C
• Boiling point: 481.08°C (rough estimate)
• Density: 1.2109 (rough estimate)
• refractive index: 1.5486 (estimate)
• storage temp.: 2-8°C
• solubility: DMSO: soluble
• form: powder
• pka: pKa -0.9/>13(DMF,t undefined) (Uncertain)
• color: yellow
• Water Solubility: <0.1 g/100 mL at 19.5 ºC
• Merck: 14,6528
• BCS Class: 2
• Stability: Stable for 1 year from date of purchase as supplied. Solutions are not stable and must be used within one working day.
• InChIKey: CYCWGQFQPAYBHG-UHFFFAOYSA-N
• CAS DataBase Reference: 21829-25-4(CAS DataBase Reference)
• NIST Chemistry Reference: Nifedipine(21829-25-4)
• EPA Substance Registry System: Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate (21829-25-4)

Description and Uses

Nifedipine (21829-25-4) is a clinically useful L-type calcium blocker.

For the management of vasospastic angina, chronic stable angina, hypertension, and Raynaud's phenomenon. May be used as a first line agent for left ventricular hypertrophy and isolated systolic hypertension (long-acting agents).

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302
• Precautionary statements: P301+P312+P330
• Hazard Codes: Xn,Xi
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36
• WGK Germany: 1
• RTECS: US7975000
• HazardClass: IRRITANT
• HS Code: 29333990
• Hazardous Substances Data: 21829-25-4(Hazardous Substances Data)
• Toxicity: LD50 in mice, rats (mg/kg): 494, 1022 orally; 4.2, 15.5 i.v. (Vater)