NifedipineD6 , 98% , 1188266-14-9
CAS NO.：1188266-14-9
Empirical Formula: C17H12D6N2O6
Molecular Weight: 352.37
MDL number: MFCD08063477
| Pack Size | Price | Stock | Quantity |
| 1mg | RMB2690.40 | In Stock |
|
| 5mg | RMB7250.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 164-165°C |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| color | Yellow |
Description and Uses
Nifedipine-d6 is intended for use as an internal standard for the quantification of nifedipine by GC- or LC-MS. Nifedipine is a dihydropyridine L-type calcium channel blocker that reduces the amplitude of spontaneous contractions in isolated rabbit ileum when used at a concentration of 1 μM. Nifedipine (1 μM) reduces TGF-β-induced calcium oscillations in human fibroblasts and prevents impairment of lung function in a mouse model of pulmonary fibrosis induced by bleomycin when administered at a dose of 10 mg/kg per day. It also reduces increases in mean arterial blood pressure induced by angiotensin II in spontaneously hypertensive rats when administered at a dose of 10 μg/kg. Formulations containing nifedipine have been used in the treatment of hypertension and angina.
Used as an antihypertensive and antianginal. A labelled dihydorpyridine calcium channel blocker.
