A6213312
Nevirapine , ≥98%(HPLC) , 129618-40-2
Synonym(s):
11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one;Nevirapine
CAS NO.：129618-40-2
Empirical Formula: C15H14N4O
Molecular Weight: 266.3
MDL number: MFCD00866928
EINECS: 603-345-0
| Pack Size | Price | Stock | Quantity |
| 1G | RMB28.80 | In Stock |
|
| 5G | RMB96.00 | In Stock |
|
| 25G | RMB288.80 | In Stock |
|
| 100G | RMB956.80 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 247°C |
| Boiling point: | 409.5°C (rough estimate) |
| Density | 1.1300 (rough estimate) |
| refractive index | 1.6200 (estimate) |
| Flash point: | 9℃ |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥22mg/mL |
| pka | 2.8(at 25℃) |
| form | powder |
| color | white to tan |
| Water Solubility | 0.1g/L(temperature not stated) |
| Merck | 14,6490 |
| BCS Class | 2 |
| Major Application | pharmaceutical (small molecule) |
| InChI | 1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20) |
| InChIKey | NQDJXKOVJZTUJA-UHFFFAOYSA-N |
| SMILES | CC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O |
| CAS DataBase Reference | 129618-40-2(CAS DataBase Reference) |
| EPA Substance Registry System | 6H-Dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-methyl- (129618-40-2) |
Description and Uses
Nevirapine and its analogues exhibit antiretroviral effect against azothymidine-resistant HIV strains. Nevirapine in combination with ZDV and ddI produced approximately 18% higher CD4 cell counts and a decrease in viral load compared with patients who took ZDV and ddI. Nevirapine is recommended with nucleosides for patients infected with HIV-1 who have experienced clinical or immunologic deterioration. The significant side effects of nevirapine are liver dysfunction and skin rashes.
amyloidosis therapy
Safety
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H225-H301+H311+H331-H370 |
| Precautionary statements | P210-P260-P280-P301+P310-P311 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-37/39 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 2 |
| RTECS | JM5562500 |
| HS Code | 29339900 |
| Storage Class | 11 - Combustible Solids |
| Hazardous Substances Data | 129618-40-2(Hazardous Substances Data) |
