4-Nitrophenyl Chloroformate , >98.0%(T) , 7693-46-1

Synonym(s):
4-Nitrophenyl chlorocarbonate, Chloroformic acid 4-nitrophenyl ester;4-Nitrophenyl chloroformate;Chloroformic acid 4-nitrophenyl ester

CAS NO.：7693-46-1

Empirical Formula: C7H4ClNO4

Molecular Weight: 201.56

MDL number: MFCD00007321

EINECS: 231-706-9

PRODUCT Properties

• Melting point: 77-79 °C(lit.)
• Boiling point: 159-162 °C19 mm Hg(lit.)
• Density: 1.5719 (rough estimate)
• refractive index: 1.6000 (estimate)
• Flash point: >110°C
• storage temp.: 2-8°C
• solubility: Soluble in acetone, chloroform, acetone, toluene and benzene.
• form: isopropanol suspension
• color: White to yellow-beige
• Water Solubility: decomposes
• Sensitive: Lachrymatory
• BRN: 518127
• Stability: Stable. Incompatible with strong bases, acids. Combustible.
• CAS DataBase Reference: 7693-46-1(CAS DataBase Reference)
• NIST Chemistry Reference: Carbonochloridic acid, 4-nitrophenyl ester(7693-46-1)
• EPA Substance Registry System: Carbonochloridic acid, 4-nitrophenyl ester (7693-46-1)

Description and Uses

4-Nitrophenyl chloroformate, also known as p-nitrophenyl chloroformate, is a coupling agent used in the synthesis of ureas, carbamates, and carbonates. It is also used as a building block in solid-phase peptide synthesis (SPPS) to obtain altered side chain functionalities in peptides.

4-Nitrophenyl chloroformate can be used:

• As a reagent for the activation of amines, alcohols and thiols.
• In the synthesis of 4-substituted phenyl derivatives of 1,2,4-triazolidindiones (urazoles).
• In the solid-phase synthesis of 3-aryl-2,4-quinazolinedione derivatives with potent anti-cancer property.
• In the preparation of poly(oxyethylene) modified dextrans.
• To synthesize a cleavable, heterobifunctional cross-linker for reversible conjugation of amines to thiol-modified DNA.

Safety

• Symbol(GHS): GHS05,GHS07
• Signal word: Danger
• Hazard statements: H314-H335
• Precautionary statements: P260-P271-P280-P301+P330+P331-P303+P361+P353-P305+P351+P338
• Hazard Codes: C,T,Xi,F
• Risk Statements: 34-36/37-23/24/25-41-36/37/38-11-67-36
• Safety Statements: 26-36/37/39-45-38-28A-36-16-27
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• F: 19-21
• Hazard Note: Toxic/Corrosive/Lachrymator
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• HS Code: 29159020