5′-O-(4,4′-Dimethoxytrityl)thymidine , 98% , 40615-39-2

Synonym(s):
DMT-T

CAS NO.：40615-39-2

Empirical Formula: C31H32N2O7

Molecular Weight: 544.59

MDL number: MFCD00010113

EINECS: 255-003-1

PRODUCT Properties

• Melting point: 114-116 °C (subl.)(lit.)
• Boiling point: 618.41°C (rough estimate)
• Density: 1.2483 (rough estimate)
• vapor pressure: 0Pa at 20℃
• refractive index: 7 ° (C=1, MeOH)
• storage temp.: 2-8°C
• solubility: Chloroform (Slightly), Methanol (Slightly)
• pka: 9.55±0.10(Predicted)
• form: Powder
• color: White to off-white
• Water Solubility: 3mg/L at 20℃
• BRN: 599297
• Stability: Store in Freezer
• InChIKey: UBTJZUKVKGZHAD-UPRLRBBYSA-N
• SMILES: COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2O)N3C=C(C)C(=O)NC3=O)(c4ccccc4)c5ccc(OC)cc5
• LogP: 4.61 at 20℃
• CAS DataBase Reference: 40615-39-2(CAS DataBase Reference)
• EPA Substance Registry System: Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]- (40615-39-2)

Description and Uses

5'-O-(4,4'-Dimethoxytrityl)thymidine is used in the solid-phase synthesis of polynucleotides and polythymidylic acids by the block coupling phosphotriester method. Further, it is used in the stereoselective synthesis of 3'-deoxy-3'-threo-hydroxymethyl nucleoside. In addition to this, it is used as a research tool for antiviral and anticancer studies.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H413
• Precautionary statements: P273
• PPE: dust mask type N95 (US), Eyeshields, Gloves
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 1-3-10
• Hazard Note: Irritant
• TSCA: TSCA listed
• HS Code: 29349990
• Storage Class: 13 - Non Combustible Solids
• Hazard Classifications: Aquatic Chronic 4